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大鼠抑郁模型的脑磁共振成像研究
引用本文:王雪琦,路长林,李丽云.大鼠抑郁模型的脑磁共振成像研究[J].中华精神科杂志,1999,0(1).
作者姓名:王雪琦  路长林  李丽云
作者单位:第二军医大学神经科学研究所、神经生物学教研室,中国科学院物理与数学研究所
摘    要:目的研究大鼠抑郁模型脑磁共振成像(MRI)的变化。方法选择OPENFIELD法评分相近的50只成年SD雄性大鼠随机分为对照组和抑郁组,每组各25只。应用分养和长期不可预见性中等强度应激所造成的大鼠抑郁模型。以敞箱实验等方法测定动物行为;MRIT2加权象对照研究抑郁大鼠脑内整体形态学及各脑区信号强度的改变。结果与对照组比较,抑郁组大鼠大脑纵裂深度加深[抑郁组(2.05±0.16)mm,对照组(1.83±0.21)mm,P<0.05]、体积扩大[抑郁组(343.00±78.87)mm3,对照组(258.00±13.59)mm3,P<0.05]。抑郁大鼠边缘系统各脑区T2加权象信号强度增加。结论提示抑郁大鼠存在脑萎缩,边缘系统各脑区水的流动性增加。

关 键 词:抑郁障碍  疾病模型.动物  大鼠.SPRAGUE-DAULEY  磁共振成像

The nuclear magnetic resonance imaging of brain in the rats of depression model
WANG Xueqi ,LU Changlin,LI Liyun,et al..The nuclear magnetic resonance imaging of brain in the rats of depression model[J].Chinese Journal of Psychiatry,1999,0(1).
Authors:WANG Xueqi  LU Changlin  LI Liyun  
Institution:WANG Xueqi *,LU Changlin,LI Liyun,et al. * Department of Neurobiology,Second Military Medical University,Shanghai 200433
Abstract:Objective To study the changes of magnetic resonance imaging in the brain of a depression model of rat. Methods The depression model of rat was produced by separation and chronic unpredictable mild stress. The behavior of rat was detected by open field test. Nuclear magnetic resonance T2 weighted imaging was used to study the changes of whole brain and intensity of T2 weighted signals of some brain areas in depressed rat. Results The brain rift was enlarged and widened. T2 weighted signals were enhanced in some brain areas of limbic system. Conclusion These data suggest that chronic depression could result in brain atrophy and increase the fluidity of water in some brain areas of limbic system.
Keywords:Depression disorder    Disease model  animal    Rats  Sprague  Dauley    Magnetic resonance imaging  
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