抑郁症患者血清胆固醇、脂蛋白和载脂蛋白的水平及其意义

目的 探讨抑郁症患者血清水平及其临床意义。方法 采用酶法及免疫比浊法检测６６例抑郁症和３６名健康对照者的血清胆固醇（ＴＣ），甘油三脂（ＴＧ），高密度脂蛋白－胆固醇（ＨＤＬ－Ｃ）低密度脂蛋白－胆固醇（ＬＤＬ－Ｃ），载脂蛋白ＡＩ（ａｐｏＡＩ）和载脂蛋白Ｂ（ａｐｏＢ）水平，并比较其中内源性抑郁患者（３４例）与非内源性抑郁患者（３２例），有自杀行为者（２５例）与无自杀行为者（４１例）的血脂水平。结果 与对

Serum levels of cholesterol, lipoproteins and apolipoproteins in patients with depressive disorder and their significance

Objective The purpose of the study was to explore the relationship between blood lipid parameters and depression or suicide Methods Serum levels of total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL C), Low density lipoprotein cholesterol (LDL C),apolipoprotein AI(apoAI) and apolipoprotein B (apoB) were measured in 66 patients with depressive disorder and 36 healthy controls using enzymatic methods and transmission immunoturdidimetry Results Serum TC and HDL C levels were significantly lower in patients with depression than in healthy controls There were no significant correlation between the blood lipid parameters and Hamilton Depression Rating Scale (HDRS) scores Serum TC, apoAI and apoB levels were significantly lower in patients with melancholia than in those without melancholia Serum TC, LDL C and apoB levels were significantly lower in depressive patients with suicidal behavior than in those without such suicidal behavior Conclusions These results suggest that depression is accompanied by lower serum levels of HDL C and TC, and lower serum TC level may be associated with suicidal behavior