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健康成人事件相关电位与神经心理学测验的相关性研究
引用本文:姚静,孙学礼,刘涛生,王洪明,舒放.健康成人事件相关电位与神经心理学测验的相关性研究[J].中华精神科杂志,2003,36(3):167-171.
作者姓名:姚静  孙学礼  刘涛生  王洪明  舒放
作者单位:1. 610041,成都,四川大学华西医院心理卫生中心
2. 成都市第四人民医院精神科
摘    要:目的 探讨事件相关电位P300的四个主要成分是否反映特定的认知功能。方法 将120名正常受试者按年龄分为三组,即20~34岁组、35~54岁组和55~70岁组,对所有受试者采用全套韦氏成人智力测验(WAIS-RC)等多项神经心理学测验以及P300进行测评,将神经心理学测验结果与P瑚结果进行Spearman等级相关分析。结果 三个年龄组中的N2潜伏期、P2波幅、N2波幅均与反映注意、短时记忆的神经心理学测验存在以下相关:在20~34岁组中,N2潜伏期与即刻视觉再生呈负相关(r=-0.352),P2波幅与即刻视觉再生呈正相关(r=0.339),N2波幅与即刻视觉再生呈正相关(r=0.331)。在35~54岁组中,N2潜伏期与数字广度、数字符号、词汇流畅均呈负相关(r分别=-0.357、-0.385、-0.316);P2波幅与延线测验B呈负相关(r=-0.427);Nl波幅与即刻逻辑记忆呈正相关(r=0.343)。在55~70岁组中,N2潜伏期与数字符号、词汇流畅呈负相关(r分别=-0.488和-0.321),与延线测验B呈正相关(r=0.366);P2波幅与数字符号呈正相关(r=0.314);N2波幅与词汇流畅呈正相关(r=0.437)。在不同的年龄组中,P300的其他指标与神经心理学测验相关性不一致。结论 P300的四个主要成分可反映一定的认知功能,但不具有特异性,部分P300指标所反映的认知功能受年龄的影响。

关 键 词:健康成人  事件相关电位  神经心理学测验  认知功能  P300
修稿时间:2002年5月30日

Correlativity of P300 event-related potentials and neuropsychological tests
YAO Jing,SUN Xue-li,LIU Tao-sheng,et al..Correlativity of P300 event-related potentials and neuropsychological tests[J].Chinese Journal of Psychiatry,2003,36(3):167-171.
Authors:YAO Jing  SUN Xue-li  LIU Tao-sheng  
Institution:YAO Jing,SUN Xue-li,LIU Tao-sheng,et al. Mental Health Center,West China Hospital,Sichuan University,Chengdu 610041,China
Abstract:Objective To test whether the subcomponents of evoked potential P_ 300 could represent specific cognitive functions. Methods All 120 normal subjects were tested with the Wechsler Adult Intelligence Scale-Revised-China(WAIS-RC), Logical Memory, Visual Reproduction, Stroop Test, Verbal Fluency, Trail Making, Tower of Hanoi (TOH), Modified Version of Wisconsin Card Sorting Tests (WCST) and P_ 300 . The subjects were divided into three age groups, i.e., the 20-34 group, 35-54 group, and 55-70 group. Results In three groups, N_2 latency, P_2 amplitude and N_1 amplitude were related to some neuropsychological tests for attention and short memory. In 20-34 age group, Visual Reproduction (immediately) related to N_2 latency ( r =-0.352), P_2 amplitude ( r =0.339) and N_1 amplitude ( r =0.331). In 35-54 age group, N_2 latency was linked to Digit Span ( r =-0.357), Digit Symbol ( r =-0.385), Verbal Fluency( r =-0.316), and P_2 amplitude to Trail Making B( r =-0.427), N_1 amplitude to Logical Memory (immediately) ( r =0.343). In 55-70 group, N_2 latency had relations with Digit Symbol ( r =-0.488), Verbal Fluency( r =-0.321), Trail Making B( r =0.366), P_2 amplitude with Digit Symbol ( r =0.314), N_1 amplitude with Verbal Fluency( r =0.437). Among different groups, the correlativity of the other P_ 300 subcomponents and some neuropsychological tests were different. Conclusion P_ 300 subcomponents of P_3, N_2, P_2, and N_1 may reflect different but not specific cognitive functions. Age could affect the correlativity of P_ 300 components and cognitive functions.
Keywords:Event-related potentials  P_300  Neuropsychological tests  Cognition  
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