| 高功能孤独症患儿全脑白质纤维的弥散张量成像研究 |
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| 引用本文： | 柯晓燕,汤天宇,洪珊珊,邹冰,储康康,周振宇,杭跃跃,李惠国,阮宗才,陆祖宏.高功能孤独症患儿全脑白质纤维的弥散张量成像研究[J].中华精神科杂志,2009,42(1):85-88. |
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| 作者姓名： | 柯晓燕 汤天宇 洪珊珊 邹冰 储康康 周振宇 杭跃跃 李惠国 阮宗才 陆祖宏 |
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| 作者单位： | 南京医科大学附属脑科医院儿童心理卫生研究中心,210029;东南大学儿童发展与学习科学教育部重点实验室;南京医科大学附属脑科医院影像科,210029; |
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| 基金项目： | 国家自然科学基金面上项目江苏省自然科学基金南京市医学重点科技发展项目 |
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| 摘 要： | Objectlve To analysis the changes of white matter fiber in autistic disorder.Methods Diffusion tensor imaging(DTI)data were obtained from 18 autistic children and 10 age-,sex-and intelligent quotient matched normal controls.Voxel-based analysis Was applied to assess the fractional anisotropy(FA)in cerebral tissues.Results Compared with the controls,the FA values in autistic children were significantly decreased in the white matter of right inferior frontal gyrus,left middle frontal gyrus and right inferior temporal gyms,and increased in the white matter of left superior parietal lobule(P＜0.001).Furthermore.the white matter changes on left middie frontal gyrus were significandy correlated with the scores of Childhond Autism Rming Scale(CARS)in autistic children(r=-0.63,P=0.005).Conclusion The white matter integrity is probably disconnected in many brain regions in children with autistic disorder.
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| 关 键 词： | 孤独性障碍 脑 磁共振成像 弥散 各向异性 白质 |
A diffusion tensor imaging study of white matter fiber in autistic children with high functioning |
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| Abstract: | |
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| Keywords: | Autistic disorderBrainDiffusion magnetic resonance imagingAnisotropyWhite matter |
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