Estrogen-IGF-1 interactions in neuroprotection: Ischemic stroke as a case study |
| |
| Institution: | 1. Department of Biochemistry & Molecular Biology, Dalhousie University, Halifax, NS, Canada;2. Department of Pathology, Dalhousie University, Halifax, NS, Canada;1. Department of Neuroscience, Medical University of South Carolina, Charleston, SC 29425, USA;2. Department of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA;3. Department of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA;1. Unidad Mixta de Investigación Cerebrovascular, Instituto de Investigación Sanitaria La Fe, Departamento de Fisiología, Universidad de Valencia, Hospital Universitario y Politécnico La Fe, Valencia, Spain;2. Unidad Mixta de Investigación Cerebrovascular, Instituto de Investigación Sanitaria La Fe, Hospital Universitario y Politécnico La Fe, Valencia Spain;1. Dipartimento di Scienze Chimiche, Università di Catania, V.le A. Doria 6, 95125 Catania, Italy;2. Istituto di Biostrutture e Bioimmagini, Consiglio Nazionale delle Ricerche, V.le A. Doria 6, 95125 Catania, Italy;3. Dipartimento di Scienze del Farmaco, Università di Catania, V.le A. Doria 6, 95125 Catania, Italy |
| |
| Abstract: | The steroid hormone 17b-estradiol and the peptide hormone insulin-like growth factor (IGF)-1 independently exert neuroprotective actions in neurologic diseases such as stroke. Only a few studies have directly addressed the interaction between the two hormone systems, however, there is a large literature that indicates potentially greater interactions between the 17b-estradiol and IGF-1 systems. The present review focuses on key issues related to this interaction including IGF-1 and sex differences and common activation of second messenger systems. Using ischemic stroke as a case study, this review also focuses on independent and cooperative actions of estrogen and IGF-1 on neuroprotection, blood brain barrier integrity, angiogenesis, inflammation and post-stroke epilepsy. Finally, the review also focuses on the astrocyte, a key mediator of post stroke repair, as a local source of 17b-estradiol and IGF-1. This review thus highlights areas where significant new research is needed to clarify the interactions between these two neuroprotectants. |
| |
| Keywords: | Estrogen IGF-1 Sex differences Neuroprotection Blood brain barrier Astrocytes Inflammation |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
