肝移植治疗肝原发性鳞状细胞癌1例

景：肝原发性鳞状细胞癌较罕见，各种治疗方法疗效不佳，预后差。 目的：随访观察1例肝移植治疗肝原发性鳞状细胞癌患者的近期疗效。 方法：观察中山大学附属第一医院1例肝原发性鳞状细胞癌患者经肝移植治疗后的情况，并回顾性分析迄今为止见于文献报道的国内外65例肝原发性鳞状细胞癌的临床表现、组织来源、治疗方法及预后。 结果与结论：该患者经肝移植后肝功能恢复正常，肿瘤标志物癌胚抗原、糖类抗原199、鳞状细胞癌抗原等均降至正常水平，恢复良好。国内外研究表明，肝原发性鳞状细胞癌的临床表现不典型，组织来源多样，手术切除、化疗等治疗方法疗效不佳，预后差。本例结果显示，肝移植治疗肝原发性鳞状细胞癌近期疗效良好。

Liver transplantation for treatment of primary squamous cell carcinoma of the liver in one case

BACKGROUND: Primary squamous cell carcinoma of the liver (PSCCL) is rare. Various treatments exhibit poor curative effects and prognosis. OBJECTIVE: To investigate the short-term curative effects of liver transplantation in treatment of primary squamous cell carcinoma in one case. METHODS: We analyzed the effect of liver transplantation in treating one case of primary squamous cell carcinoma of the liver in the First Affiliated Hospital of Sun Yat-sen University and retrospectively analyzed the clinical manifestations, tissue origin, therapeutic method and prognosis of 65 cases of the primary squamous cell carcinoma of the liver at home and abroad. RESULTS AND CONCLUSION: The patient recovered well after liver transplantation, liver function returned to normal, tumor markers such as carcinoembryonic antigen, carbohydrate199 and squamous cell carcinoma antigen decreased to normal levels. Domestic and foreign data show that primary squamous cell carcinoma of the liver presents atypical clinical manifestations, variety of tissue sources, poor efficacy and prognosis of surgical excision, chemotherapy and other treatments. Results from the present case showed that liver transplantation for treatment of primary squamous cell carcinoma of the liver exhibits good curative effects, but further investigations are needed to estimate the long-term effect on such cases.