Dose-dependent neuroprotective effect of enoxaparin on cold-induced traumatic brain injury |
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Authors: | Ilknur Keskin MYalcin Gunal Nilufer Ayturk Ulkan Kilic Mehmet Ozansoy Ertugrul Kilic |
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Institution: | 1. Department of Histology and Embryology, Medipol University, Istanbul, Turkey;Regenerative and Restorative Medical Research Center (REMER), Medipol University, Istanbul, Turkey;2. Department of Physiology, Medipol University, Istanbul, Turkey;Regenerative and Restorative Medical Research Center (REMER), Medipol University, Istanbul, Turkey;3. Regenerative and Restorative Medical Research Center (REMER), Medipol University, Istanbul, Turkey;Department of Medical Biology, Medipol University, Istanbul, Turkey |
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Abstract: | Recent evidence exists that enoxaparin can reduce brain injury because of its anticoagulant activity. To investigate the potential therapeutic effect of enoxaparin on cold-induced traumatic brain injury, at 20 minutes after modeling, male BALB/c mouse models of cold-induced traumatic brain injury were intra-peritoneally administered 3 and 10 mg/kg enoxaparin or isotonic saline solution. Twenty-four hours later, enoxaparin at 10 mg/kg greatly reduced infarct volume, decreased cell apoptosis in the cortex and obviously increased serum level of total antioxidant status. By contrast, administration of enoxaparin at 3 mg/kg did not lead to these changes.These findings suggest that enoxaparin exhibits neuroprotective effect on cold-in-duced traumatic brain injury in a dose-dependent manner. |
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Keywords: | nerve regeneration neuroprotection traumatic brain injury cold-induced brain injury enoxaparin anti-oxidative apoptosis neural regeneration |
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