Meta analysis of olfactory ensheathing cell transplantation promoting functional recovery of motor nerves in rats with complete spinal cord transection |
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Authors: | Jun Liu;Ping Chen;Qi Wang;Yu Chen;Hailong Yu;Junxiong Ma;Mingming Guo;Meihui Piao;Weijian Ren;Liangbi Xiang; |
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Institution: | Jun Liu;Ping Chen;Qi Wang;Yu Chen;Hailong Yu;Junxiong Ma;Mingming Guo;Meihui Piao;Weijian Ren;Liangbi Xiang;Department of Orthopedics,General Hospital of Shenyang Military Command Area of Chinese PLA;Department of Gastroenterology,Taian Central Hospital; |
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Abstract: | OBJECTIVE:To evaluate the effects of olfactory ensheathing cell transplantation on functional recovery of rats with complete spinal cord transection.DATA SOURCES:A computer-based online search of Medline (1989–2013), Embase (1989–2013), Cochrane library (1989–2013), Chinese Biomedical Literature Database (1989–2013), China National Knowledge Infrastructure (1989–2013), VIP (1989–2013), Wanfang databases (1989–2013) and Chinese Clinical Trial Register was conducted to collect randomized controlled trial data regarding olfactory ensheathing cell transplantation for the treatment of complete spinal cord transection in rats.SELECTION CRITERIA:Randomized controlled trials investigating olfactory ensheathing cell transplantation and other transplantation methods for promoting neurological functional recovery of rats with complete spinal cord transection were included in the analysis. Meta analysis was conducted using RevMan 4.2.2 software.MAIN OUTCOME MEASURES:Basso, Beattie and Bresnahan scores of rats with complete spinal cord transection were evaluated in this study.RESULTS:Six randomized controlled trials with high quality methodology were included. Meta analysis showed that Basso, Beattie and Bresnahan scores were significantly higher in the olfactory ensheathing cell transplantation group compared with the control group (WMD = 3.16, 95% CI (1.68, 4.65); P < 0.00001).CONCLUSION:Experimental studies have shown that olfactory ensheathing cell transplantation can promote the functional recovery of motor nerves in rats with complete spinal cord transection. |
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Keywords: | nerve regeneration olfactory ensheathing cells cell transplantation spinal cord injury complete transection BBB scores meta analysis |
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