|
|||||
|
|
Plasticity of language pathways in patients with low-grade glioma A diffusion tensor imaging study |
|
| Authors: | Gang Zheng Xiaolei Chen Bainan Xu Jiashu Zhang Xueming Lv Jinjiang Li Fangye Li Shen Hu Ting Zhang Ye Li |
| Institution: | Gang Zheng (Department of Neurosurgery, Chinese PLA General Hospital, Chinese PLA Postgraduate Medical School, Beijing 100853, China)；Xiaolei Chen (Department of Neurosurgery, Chinese PLA General Hospital, Chinese PLA Postgraduate Medical School, Beijing 100853, China)；Bainan Xu (Department of Neurosurgery, Chinese PLA General Hospital, Chinese PLA Postgraduate Medical School, Beijing 100853, China)；Jiashu Zhang (Department of Neurosurgery, Chinese PLA General Hospital, Chinese PLA Postgraduate Medical School, Beijing 100853, China)；Xueming Lv (Department of Neurosurgery, Chinese PLA General Hospital, Chinese PLA Postgraduate Medical School, Beijing 100853, China)；Jinjiang Li (Department of Neurosurgery, Chinese PLA General Hospital, Chinese PLA Postgraduate Medical School, Beijing 100853, China)；Fangye Li (Department of Neurosurgery, Chinese PLA General Hospital, Chinese PLA Postgraduate Medical School, Beijing 100853, China)；Shen Hu (Department of Neurosurgery, Chinese PLA General Hospital, Chinese PLA Postgraduate Medical School, Beijing 100853, China)；Ting Zhang (Department of Neurosurgery, Chinese PLA General Hospital, Chinese PLA Postgraduate Medical School, Beijing 100853, China)；Ye Li (Department of Neurosurgery, Chinese PLA General Hospital, Chinese PLA Postgraduate Medical School, Beijing 100853, China)； |
| Abstract: | Knowledge of the plasticity of language pathways in patients with low-grade glioma is important for neurosurgeons to achieve maximum resection while preserving neurological function. The current study sought to investigate changes in the ventral language pathways in patients with low-grade glioma located in regions likely to affect the dorsal language pathways. The results revealed no significant difference in fractional anisotropy values in the arcuate fasciculus between groups or between hemispheres. However, fractional anisotropy and lateralization index values in the left inferior longitudinal fasciculus and lateralization index values in the left inferior fronto-occpital fasciculus were higher in patients than in healthy subjects. These results indicate plasticity of language pathways in patients with low-grade glioma. The ventral language pathways may perform more functions in patients than in healthy subjects. As such, it is important to protect the ventral language pathways intraoperatively. |
| Keywords: | neural regeneration neuroimaging low-grade glioma plasticity language pathways diffusion tensor imaging fractional anisotropy lateralization index ventral language pathway dorsal language pathway glioma grants-supported paper photographs-containing paper neuroregeneration |