| 石菖蒲提取物干预发育期反复惊厥大鼠脑内r-氨基丁酸A受体a1亚单位的表达 |
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| 引用本文： | 刘利群,毛定安,迟克强,李杏芳,薄涛,郭锦明,易著文.石菖蒲提取物干预发育期反复惊厥大鼠脑内r-氨基丁酸A受体a1亚单位的表达[J].中国神经再生研究,2011,6(6):412-417. |
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| 作者姓名： | 刘利群 毛定安 迟克强 李杏芳 薄涛 郭锦明 易著文 |
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| 作者单位： | 中南大学湘雅二医院,中南大学湘雅二医院,中南大学湘雅二医院,中南大学湘雅二医院,中南大学湘雅二医院,湖南中医药大学药学院,中南大学湘雅二医院 |
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| 基金项目： | 湖南省自然科学基金资助（09JJ6032） |
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| 摘 要： | Extracts from Rhizoma Acori Tatarinowii (Grassleaf Sweetflag Rhizome,Shichangpu) have been shown to improve learning and memory,reduce anxiety,allay excitement,and suppress seizures.Rhizoma Acori Tatarinowii extracts interact with γ-aminobutyric acid and activate the γ-aminobutyric acid type A receptor,although few studies have addressed the precise effects of γ-aminobutyric acid type A receptor α1 subunit.In the present study,γ-aminobutyric acid type A receptor α1 subunit protein expression in the cerebral cortex and hippocampus,and pathological scores of brain injury,were significantly greater following recurrent seizures,but significantly decreased following treatment with Rhizoma Acori Tatarinowii extracts.These results indicated that Rhizoma Acori Tatarinowii extracts down-regulated γ-aminobutyric acid type A receptor α1 subunit protein expression in the cerebral cortex and hippocampus and protected seizure-induced brain injury during development.
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| 关 键 词： | seizure brain injury γ-aminobutyric acid A receptor cortex hippocampus extracts of Rhizoma Acori Tatarinowii |
Effects of Rhizoma Acori Tatarinowii extracts on gamma-aminobutyric acid type A receptor alpha 1 subunit brain expression during development in a recurrent seizure rat model |
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| Liqun Liu,Ding''an Mao,Keqiang Chi,Xingfang Li,Tao Bo,Jinming Guo,Zhuwen Yi.Effects of Rhizoma Acori Tatarinowii extracts on gamma-aminobutyric acid type A receptor alpha 1 subunit brain expression during development in a recurrent seizure rat model[J].Neural Regeneration Research,2011,6(6):412-417. |
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| Authors: | Liqun Liu Ding'an Mao Keqiang Chi Xingfang Li Tao Bo Jinming Guo Zhuwen Yi |
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| Institution: | Department of Pediatrics, Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China,Department of Pediatrics, Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China,,Department of Pediatrics, Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China,Department of Pediatrics, Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China,College of Pharmacy, Hunan University of Traditional Chinese Medicine, Changsha 410007, Hunan Province, China,Department of Pediatrics, Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China |
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