纳米羟基磷灰石/聚酰胺66人工椎体置入与椎体重建

摘要 背景：发生于胸腰椎的骨嗜酸性肉芽肿临床较少见，对于病灶切除后的椎体缺损，已有不同生物材料的椎体替代物用于临床，但是纳米羟基磷灰石/聚酰胺66人工椎体在此病的临床应用还鲜有报道。 目的：观察纳米羟基磷灰石/聚酰胺66人工椎体在脊椎嗜酸性肉芽肿病椎切除术后椎体重建的效果。 方法：回顾性分析2005-01/2009-12重庆医科大学附属第一医院骨科收治的经病理证实的胸腰椎嗜酸性肉芽肿患者15例，全部行前路病灶切除、椎体间行纳米羟基磷灰石/聚酰胺66人工椎体置入、前路钉板系统内固定治疗。观察切口愈合情况、伤口并发症及脊髓功能恢复情况。 结果与结论：15例患者全部获得随访，平均随访2.1年。全部痊愈，脊髓功能得到恢复，无复发及并发症发生。提示脊椎嗜酸性肉芽肿病椎切除后椎体间纳米羟基磷灰石/聚酰胺66人工椎体置入、前路钉板系统内固定可以获得良好的椎体重建效果。 关键词：纳米羟基磷灰石/聚酰胺66；人工椎体；胸腰椎；嗜酸性肉芽肿；椎体重建 doi:10.3969/j.issn.1673-8225.2010.47.037

Nano-hydroxyapatite/polyamide 66 artificial vertebrae implantation for vertebral reconstruction

Abstract BACKGROUND: Thoracolumbar vertebral eosinophilic granuloma is uncommonly encountered in clinical practice. Vertebral body replacement with different biological materials is used for the reconstruction of the osseous defect after corpectomy. But it has been few researched about the nano-hydroxyapatite/polyamide 66 artificial vertebral body in the clinical application of the disease until now. OBJECTIVE: To observe the efficacy of nano-hydroxyapatite/polyamide 66 artificial vertebral body on the vertebral reconstruction of eosinophilic granuloma after corpectomy. METHODS: Fifteen patients with thoracolumbar vertebral eosinophilic granuloma confirmed by pathological detection were admitted to Department of Orthopedics at the First Affiliated Hospital of Chongqing Medical University from January 2005 to December 2009, their therapeutic effects were retrospectively analyzed. All the cases underwent anterior lesions removal, implantation of nano-hydroxyapatite/polyamide 66 artificial vertebral body, and anterior screw-plate fixation system. The incision healing, wound complication and recovery of spinal cord function were determined. RESULTS AND CONCLUSION: All 15 patients followed up for a mean of 2.1 years, all of them were cured without recurrence and complications. The spinal cord function recovered. After removal of vertebral eosinophilic granuloma, implantation of nano-hydroxyapatite/polyamide 66 artificial vertebral body, and anterior screw-plate fixation system can obtain good therapeutic effect of vertebral reconstruction.