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远交系小鼠作为轻度认识障碍动物模型的可行性
引用本文:王芳,许文华,王超,黄德武,陈贵海.远交系小鼠作为轻度认识障碍动物模型的可行性[J].中国神经再生研究,2010,5(21):1650-1656.
作者姓名:王芳  许文华  王超  黄德武  陈贵海
作者单位:安徽医科大学第一附属医院,Department of Neurology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China,Department of Neurology, the People’s Hospital of Huaibei City, Huaibei 235000, Anhui Province, China,Laboratory of Animal Center, Anhui Medical University, Hefei 230032, Anhui Province, China,安徽医科大学第一附属医院
摘    要:轻度认知障碍(MCI)患者常进展为阿尔茨海默病,其最早症状之一是空间学习记忆的减退。终止或延缓这一顽固性疾病造成损害的最佳策略是使用该病变调剂或针对这些临床前症状的人群给予认知促进剂。但是迄今为止,尚缺少MCI的动物模型以帮助评估治疗策略的有效性。因此,本研究的目的是获得MCI的小鼠模型。分别对两个年龄组的小鼠(昆明5月和12.5月和ICR 7月和12月)进行了研究。 Morris水迷宫和六臂水迷宫被用来评估是否中年小鼠会表现出空间学习和记忆障碍。结果表明,与各自的年轻小鼠相比,中年鼠在这两种方法上存在明显空间记忆受损,在六臂水迷宫仅出现轻度空间学习的损害。因此,这些远交系鼠(昆明和ICR小鼠)可作为MCI的自然动物模型,特别是针对记忆障碍的研究。

关 键 词:轻度认知功能障碍  模型  Morris水迷宫  放射状水迷宫  小鼠

Can outbred mice be used as a mouse model of mild cognitive impairment?
Wang Fang,Xu Wenhu,Wang Chao,Huang Dewu and Chen Guihai.Can outbred mice be used as a mouse model of mild cognitive impairment?[J].Neural Regeneration Research,2010,5(21):1650-1656.
Authors:Wang Fang  Xu Wenhu  Wang Chao  Huang Dewu and Chen Guihai
Abstract:Deficits in spatial learning and memory are some of the earliest symptoms in mild cognitive impairment (MCI). However, there are few valid MCI animal models available to evaluate putative therapeutic strategies. The aim of this study was to obtain a natural animal model of MCI. Outbred Kunming (aged 5 and 12.5 months) and ICR (7 and 12 months) mice were utilized in the present study. Morris water maze and radial six-arm water maze (RAWM) were simultaneously used to evaluate impaired spatial learning and memory in middle-aged mice (approximately 12 months of age). Compared with younger mice in the respective groups, the middle-aged mice suffered visible impairment of spatial memory in the Morris water maze and RAWM, and mild spatial learning deficiency occurred in the RAWM study alone. Thus outbred Kunming and ICR mice could be utilized as a natural animal model for MCI, in particular for memory impairment studies.
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