Department of Neurosurgery, Changzheng Hospital Affiliated to the Second Military Medical University of Chinese PLA, Shanghai Neurosurgery Institute;Department of Neurosurgery, Changzheng Hospital Affiliated to the Second Military Medical University of Chinese PLA;Department of Neurosurgery, General Hospital of Nanjing Military Area Command of Chinese PLA;Department of Neurosurgery, Changzheng Hospital Affiliated to the Second Military Medical University of Chinese PLA, Shanghai Neurosurgery Institute;Department of Neurosurgery, Changzheng Hospital Affiliated to the Second Military Medical University of Chinese PLA, Shanghai Neurosurgery Institute
Abstract:
BackgroundPrevious researches demonstrated that neurovascular decompression could cure hypertension; however, whether it could effectively control refractory hypertension after hypertensive cerebral hemorrhage should be further studied.ObjectiveTo observe the effect of neruovascular compression on intracranial vagus for blood pressure of dogs and investigate the effect of neurovascular decompression on blood pressure of patients with hypertensive cerebral hemorrhage.DesignRandomized controlled animal study, clinical effects and retrospective analysis.SettingDepartment of Neurosurgery, Changzheng Hospital Affiliated to the Second Military Medical University of Chinese PLA.MaterialsThe experiment was carried out in the Department of Neurosurgery, Changzheng Hospital Affiliated to the Second Military Medical University of Chinese PLA from May to October 2006. A total of 15 healthy adult dogs of both genders were randomly divided into experimental group (n =10) and control group (n =5). Clinical observation: A total of 41 patients with hypertensive cerebral hemorrhage were selected from the Department of Neurosurgery, General Hospital of Nanjing Military Area Command of Chinese PLA and the Department of Neurosurgery, Changzheng Hospital Affiliated to the Second Military Medical University of Chinese PLA from October 1999 to October 2006. Among them, one patient had brain stem hemorrhage. There were 27 males and 14 females aged from 41 to 66 years. Inclusion criteria: All patients were diagnosed with CT examination once or several times. Volume of hematoma ranged from 50 to 120 mL and had obviously operative indication. All patients provided consents. In addition, another 281 patients with hypertensive cerebral hemorrhage who received traditionally internal and surgical therapies in our departments of neurosurgery, neurology and emergency room were selected in the control group.Methods