不同疗程无抽搐电休克治疗难治性精神分裂症的对照研究

目的比较不同疗程无抽搐电休克治疗（EMCT）对难治性精神分裂症TRS的疗效与副反应。方法将102例难治性精神分裂症患者随机分为两组，一组给予12次MECT治疗（实验组n=52），另一组给予8次MECT治疗（对照组n=50）；观察两组样本的有效率、阳性与阴性症状量表（PANSS）总分、治疗相关症状量表（TESS）总分、韦克斯勒记忆量表（WMS）总分变化。结果两组有效率在MECT治疗4次末、8次末、12次未表现出统计学差异（P均＞0.05），各组组内前后比较也未表现出统计学差异（P均＞0.05）；PANSS总分在各测量时点组间差异不显著（P均＞0.05），但第4次、8次、12次评分与入院时相比差异有统计学意义（P均＜0.05）；TESS总分各时点测量组间差异无显著性，但在第8次时与入组时比较差异具显著性（P＜0.01）；WMS各测量时点组间及各组与入组时比较均无显著性意义（P均＞0.05）。结论不同疗程MECT对TRS的短期疗效、副反应的影响无差别；MECT对TRS有效、安全；应当进一步研究MECT的作用机制。

A comparative study on treatment of treatment-refractory schizophrenia with different periodical modified electroconvulsive therapy

Objective To investigate the effects and side effects of different period of modified e lectroconvulsive therapy （modified electroconvulsive therapy, MECT） on treatment--refraetive schizophrenia （treatment--refractive schizophrenia, TRS）. Methods 102 cases were randomly divided into 2 groups （experimental group, n= 52 ; control group, n= 50）. The ext;erimental group received 12 times of MECT, control group was coped with 8 times of MECT. Changes in effective rate, score of positive and negative syndrome scale （positive and negative syndrome scale, PANSS） and treatment emergent symptoms scale （treatment emergent symptoms scale, TESS）, Wechsler memory scale （Wechsler memory scale, WMS） was then measured 24 hours after accepting 4th, 8th and 12th MECT. Results No significant difference in effective rate was observed between 2 groups and between pretreatment and post-treatment at each time points （P）0.05）. No significant difference in overall scales of PANSS was found between groups （P〉 0.05）, however, the base line showed a remarkable difference between groups at the indicated time points （P 〈 0.05）. Furthermore, the overall score of TESS between baseline and the value collected at 8th MECT displayed a significant difference （P 〈 0.01）. No difference was found in the overall score of WMS between 2 groups. （P 〉 0.05）. Conclusions There is no difference in short-termed effects and side--effects on TRS received different period of MECT, suggesting MECT is an ef fective and safe way for coping with TRS. Its mechanism should be further investigated.