五-羟色胺2A受体基因A1438G多态性与精神疾病患者自杀未遂的关联性研究

目的 探讨五-羟色胺2A(5-HT2A)受体基因A1438G多态性与精神疾病患者的自杀未遂之间的关系。方法 共有52例有自杀未遂的精神疾病患者和64例无自杀的精神疾病患者及63例正常人入组研究。所有入组者按常规方法提取DNA,用限制性片段长度多态性方法分析5-HT2A受体基因的多态性。结果 自杀未遂组的A1438G多态性位点的G等位基因频率(0.52)高于正常对照组(0.39)x2=3.91,P<0.05。自杀未遂组与正常对照组间的基因型分布的差异也有显著性(x2=6.12,P<0.05)。结论 精神疾病患者的自杀未遂与5-HT2A受体基因的A1438G多态性有关,G等住基因可能是自杀行为的危险因素。

Association of A1438G Polymorphism of Serotonin 2A Receptor Gene with Attempted Suicide in Psychiatric Patients

Objective The purpose of the study was to investigate the association of A1438G polymorphism of 5 -HT2A receptor gene with attempted suicide in psychiatric patients. Methods A total of 52 cases of psychiatric patients with attempted suicide, 64 cases of psychiatric patients with no suicide and 63 normal controls were included in the study. The polymorphism of the gene was analyzed using a polymerase chain reaction (PCR) -based restriction fragment length polymorphism (RFLP) analysis. Results Allele frequencies for A1438G polymorphism in the 5 - HT2A receptor gene showed a significant excess of G variant in attempted suicidal group (x2 = 3. 9,P< 0. 05). There were significant differences in the distribution of the genotypes between attempted suicidal group and normal controls (x2 = 6. 12,P< 0. 05). Conclusions The excess of 1438G variant in the 5-HT2A receptor gene may be a risk factor for the attempted suicide with psychiatric patient.