抑郁症患者血清脑源性神经营养因子水平及其相关因素

目的 探讨抑郁症患者血清脑源性神经营养因子水平及其相关因素,为防治抑郁症提供重要依据.方法 采用酶联免疫吸附法和汉密尔顿抑郁量表分别测定40例抑郁症患者(患者组)的血清BDNF水平和抑郁严重程度,并与49名正常者(对照组)进行对比分析.结果 患者组治疗前血清BDNF水平明显降低,与对照组比较差异有统计学意义(P＜0.01).患者组治疗8周末血清BDNF水平明显升高,HAMD总分明显降低,与治疗前比较差异有统计学意义(P＜0.05).患者组治疗前后血清BDNF水平与性别及年龄均呈负相关,差异具有统计学意义(P＜0.05),与受教育程度、病程及HAMD总分比较无统计学意义(P＞0.05).结论 抑郁症患者存在血清BDNF水平的下降,抗抑郁治疗可改善抑郁症状,并显著提高血清BDNF水平.

An analysis of serum levels of BDNF and related factors in depressive patients

Objective To explore the serum＇levels of Brain--derived neurotrophic factor （BDNF） in patients with depression. Methods Serum BDNF levels were measured in 40 depression and 48 healthy controls. The severities of depression were measured with the 17--item Hamilton Rating Scale for Depression （HAMD-17）, before and after antidepressant treatment, respectively. Results The participants with depression had lower Serum BDNF levels than the controls （P〈0.01）, and increased significantly at the end of 8 weeks after treatment（P〈0.05）, with decreased HAMD--17（P〈0.01）. It was estimated that the Serum BDNF levels had negative relationship with sex and age（P〈0.05）, whereas no relationship with education, disease duration, and HAMD--17 scores（P〉0.05）. Conclusions The resuits indicate that, compared to antidepressant treatment, the patients with depression prior to treatment have worse executive function performance and lower Serum BDNF.