脑卒中后抑郁患者血清白细胞介素-6水平变化的研究

目的研究脑卒中后抑郁(PSD)患者血清白细胞介素-6(IL-6)水平变化,探讨PSD患者的抑郁与免疫功能变化的关系。方法采用放射免疫法检测59例PSD患者、36例非PSD患者及43例正常人的血清IL-6水平。59例PSD患者随机给予抗抑郁治疗 脑血管病恢复期方案治疗(n=29)或仅给予脑血管病恢复期方案治疗(n=30),观察患者治疗前后血清IL-6水平变化。结果治疗前,PSD组血清IL-6水平显著高于非PSD组(P<0.01)和正常对照组(P<0.01);治疗后,PSD抗抑郁治疗组与PSD未抗抑郁治疗组相比,HAMD评分(P<0.01)和IL-6水平(P<0.01)均显著降低。在PSD组治疗前、PSD抗抑郁治疗组及PSD未抗抑郁治疗组治疗后,HAMD评分与血清IL-6水平相关系数分别为0.375(P<0.01)、0.452(P<0.01)和0.397(P<0.01)呈显著性正相关。结论PSD患者血清IL-6水平明显升高并且与抑郁程度相关。

Serum interleukin-6 level in patients with poststroke depression

Objective To study the changes of serum interleukin-6 (IL-6) level in patients with poststroke depression (PSD) and investigate the relationship of serum IL-6 with depression. Methods Fifty-nine patients with PSD, 36 with non-PSD and 43 normal controls were enrolled in this study. The 59 patients with PSD were randomly administered with anti-depressant therapy conventional therapy (n=29) or with routine therapy alone (n=30). Serum IL-6 levels were measured using radioimmunoassay. The degree of depression was evaluated by the Hamilton rating scale for depression (HAMD). Results Before treatment, serum IL-6 levels in PSD group were significantly higher than in the non-PSD and normal control group (P<0.01). After treatment, both the score of HAMD (P<0.01) and the level of IL-6 (P<0.01) in anti-depressant therapy (ADT) group were significantly lower than those in the conventional therapy group. There were significantly positive correlation in the serum IL-6 levels and the HAMD score in the PSD group before treatment (r=0.375, P<0.01), and in the ADT group (r=0.452, P<0.01) and conventional therapy group (r=0.397, P<0.01) after treatment. Conclusions Serum IL-6 levels increase significantly in patients with PSD and are associated with the degree of depression.