| 颞叶内侧癫痫患者海马区胶质细胞中GFAP、GLAST和GLT-1的表达 |
| |
| 引用本文： | 罗景华,任榕娜,杨朋范.颞叶内侧癫痫患者海马区胶质细胞中GFAP、GLAST和GLT-1的表达[J].国际神经病学神经外科学杂志,2009,36(6). |
| |
| 作者姓名： | 罗景华 任榕娜 杨朋范 |
| |
| 作者单位： | 1. 福建医科大学福州总院临床医学院儿科,福建省福州市,350025
2. 福建医科大学福州总院临床医学院神经外科癫痫中心,福建省福州市,350025 |
| |
| 摘 要： | 目的研究胶质纤维酸性蛋白(GFAP)及谷氨酸-胱氨酸转运体(GLAST)、神经胶质谷氨酸转运体(GLT-1)在颞叶癫痫患者海马区的表达情况。方法取40例难治性颞叶内侧癫痫患者在手术中切除的海马组织,根据在光镜下观察到的神经元丢失情况,分为海马硬化组(A组)23例和海马非硬化组(B组)17例,通过免疫组化法检测两组GFAP、GLAST、GLT-1的表达情况。结果A组GFAP的表达与B组比较,总海马区域、CA1区、CA2区、齿状回表达增加(P<0.01)。A组GLAST的表达与B组比较,海马总区域、齿状回差异无显著性(P>0.05)、CA1区减少(P<0.05)、CA2区则增加(P<0.05)。A组GLT-1的表达与B组比较,总海马区域、CA1区减少(P<0.01)、CA2区增加(P<0.01),齿状回差异无显著性(P>0.05)。结论颞叶内侧癫痫患者海马各区GFAP表达增加,GLAST、GLT-1在海马CA1区减少、CA2区表达增加,提示癫痫发作后海马区谷氨酸转运体重新分布可能是难治性癫痫发病机制之一。
|
| 关 键 词： | 胶质细胞 胶质纤维酸性蛋白 谷氨酸-胱氨酸转运体 神经胶质谷氨酸转运体 颢叶内侧癫痫 海马 |
Expression of GFAP,GLAST and GLT-1 in gliacytes of patients with mesial temporal lobe epilepsy |
| |
| LUO Jing-Hua,REN Rong-Na,YANG Peng-Fan.Expression of GFAP,GLAST and GLT-1 in gliacytes of patients with mesial temporal lobe epilepsy[J].Journal of International Neurology and Neurosurgery,2009,36(6). |
| |
| Authors: | LUO Jing-Hua REN Rong-Na YANG Peng-Fan |
| |
| Institution: | LUO Jing-Hua,REN Rong-Na,YANG Peng-Fan.Department of Pediatrics,Fuzhou General Hospital,Fujian Medical University,Fuzhou 350025,China |
| |
| Abstract: | Objective To determine the expression of glial fibrillary acidic protein(GFAP),glutamate-cystine transporter(GLAST),and glial glutamate transporter 1(GLT-1)in patients with mesial temporal lobe epilepy.Methods The medial temporal cortex and hippocampus from 40 patients with temporal lobe epileptogenic were harvested in surgery.The patients were classified into two groups based on the hippocampus was characterized by neuronal loss and astroglial proliferation of the surgically resected hippocampi sclerotic h... |
| |
| Keywords: | astrocytes glial fibrillary acidic protein glutamate-cystine transporter glial glutamate transporter 1 mesial temporal lobe epilepsy Hippocampus |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
