首页 | 本学科首页   官方微博 | 高级检索  
检索        


Subjective cognitive decline in cognitively normal elders from the community or from a memory clinic: Differential affective and imaging correlates
Authors:Audrey Perrotin  Renaud La Joie  Vincent de La Sayette  Louisa Barré  Florence Mézenge  Justine Mutlu  Denis Guilloteau  Stéphanie Egret  Francis Eustache  Gaël Chételat
Institution:1. INSERM, U1077, Caen, France;2. Université de Caen Normandie, UMR-S1077, Caen, France;3. Ecole Pratique des Hautes Etudes, UMR-S1077, Caen, France;4. CHU de Caen, U1077, Caen, France;5. CHU de Caen, Service de Neurologie, Caen, France;6. CEA, DRF/I2BM, LDM-TEP Group, Caen, France;7. CNRS, UMR ISTCT 6301, LDM-TEP Group, Caen, France;8. INSERM U930, Université François Rabelais de Tours, CHRU de Tours, Tours, France
Abstract:

Introduction

Subjective cognitive decline (SCD) could indicate preclinical Alzheimer's disease, but the existing literature is confounded by heterogeneous approaches to studying SCD. We assessed the differential cognitive, affective, and neuroimaging correlates of two aspects of SCD: reporting high cognitive difficulties on a self-rated questionnaire versus consulting at a memory clinic.

Methods

We compared 28 patients from a memory clinic with isolated SCD, 35 community-recruited elders with similarly high levels of self-reported cognitive difficulties, and 35 community-recruited controls with low self-reported cognitive difficulties.

Results

Increased anxiety and amyloid β deposition were observed in both groups with high self-reported difficulties, whereas subclinical depression and (hippocampal) atrophy were specifically associated with medical help seeking. Cognitive tests showed no group differences.

Discussion

These results further validate the concept of SCD in both community- and clinic-based groups. Yet, recruitment methods influence associated biomarkers and affective symptomatology, highlighting the heterogeneous nature of SCD depending on study characteristics.
Keywords:Alzheimer's disease  Subjective cognitive decline  Cognitive complaint  Preclinical  Amyloid β  Florbetapir-PET  MRI  Atrophy  Hippocampus  Anxiety  Depression
本文献已被 ScienceDirect 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号