Diurnal pattern of cortisol output in postnatal depression |
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| Authors: | Alyx Taylor Vivette Glover Maureen Marks Martin Kammerer |
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| Affiliation: | 1. Imperial College London, Institute of Reproductive and Developmental Biology, Hammersmith Campus, Du Cane Road, London W12 0NN, UK;2. King''s College London, School of Biomedical and Health Sciences, Franklin-Wilkins Building, Stamford Street, London SE1 9NH, UK;3. King''s College London, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK;4. University of Applied Sciences, Department of Applied Psychology, Minervastrasse 30, CH 8032 Zurich, Switzerland |
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| Abstract: | This study investigated the diurnal output of saliva cortisol in women with symptoms of depression postnatally. Twenty-one depressed and 30 non-depressed women at 7.5 weeks postpartum, and 21 non-perinatal controls, collected saliva at waking, 30 min, and 3 and 12 h postwaking. Women who were not depressed postnatally showed a pattern of cortisol secretion over the day similar to non-perinatal controls. There was a significant difference in diurnal pattern between postnatally depressed and postnatally non-depressed women, due to a difference in the first two time points (waking and +30 min): compared to the other two groups who each had a significant increase in cortisol levels from waking to +30 min, the depressed women had significantly higher cortisol levels at waking and no increase at +30 min. The lack of a morning rise in the depressed women is similar to that reported for posttraumatic stress disorder and chronic fatigue syndrome and may reflect a response, in vulnerable women, to the marked cortisol withdrawal that occurs after delivery. |
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| Keywords: | HPA axis Depression Cortisol Cortisol awakening response Postnatal Postpartum |
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