多发性硬化的性别差异

多发性硬化在女性人群中的发病率明显高于男性，而且呈逐年升高之趋势。许多研究表明，性别对多发性硬化患者的病情进展、疗效及转归具有不同程度的影响，是一项独立影响因素。本文旨在探讨可能受多发性硬化性别差异影响的要素，诸如发病率、发病机制、临床进程、磁共振成像、治疗原则等。

Gender-related differences in multiple sclerosis patients

Ahhough multiple sclerosis （MS） affects both women and men, women are more susceptible to MS than men with increasing incidence and prevalence. Accumulating evidence indicates that gender appears to play a critical role in the development, efficacy and prognosis of MS, and therefore should be considered as an independent influencing factor. In this review, factors that can potentially explain the gender-biased observations in MS are discussed, which include incidence and prevalence, mechanism, course and prognosis, imaging, treatment principles.