轻度认知功能障碍淋巴细胞及炎症蛋白检测

目的探讨MCI认知功能与淋巴细胞及炎症蛋白的关系。方法研究阿尔茨海默病（AD,36例）、轻度认知障碍（MCI,34例）及认知功能正常老年人（认知正常组,36人）的外周血淋巴细胞亚群、免疫球蛋白及炎性蛋白的差异。结果认知正常组、MCI组与AD患者的免疫球蛋白G（IgG）浓度中位数依次为10.5g/L、10.6g/L、13.1g/L（χ2=14.28,P〈0.01）;辅助性T淋巴细胞（TH）比例的中位数依次为41%、35%、37%（χ2=9.96,P〈0.01）;三组间差异有统计学意义。其中认知正常组与MCI组的IgG差异无统计学意义（Z=0.64,P=0.52）,而AD组IgG水平高于MCI组（Z=3.26,P〈0.01）和认知正常组（Z=3.22,P〈0.01）;认知正常组TH高于AD组（Z=2.55,P〈0.05）和MCI组（Z=2.95,P〈0.01）,而MCI组与AD组的TH差异无统计学意义（Z=0.18,P=0.86）。结论 IgG可能在AD与MCI、认知功能正常者的鉴别方面具有重要意义;TH水平降低可能是认知功能受损的标志。

Examinations of lymphocytes and inflammatory proteins in mild cognitive impairment

Objective：To investigate the relationship between inflammation and cognitive function.Methods：The differences of peripheral blood lymphocyte subsets,immunoglobulin and inflammatory protein among Alzheimer＇s disease （AD,n=36）,mild cognitive impairment （MCI,n=34） and healthy elderly （n=36） were examined.Results：The median levels of immunoglobulin G （IgG） and the percentages of helper T lymphocytes （TH） were 10.5g/L,10.6g/L,13.1g/L （χ2=14.28,P0.01） and 41%,35%,37% （χ2=9.96,P0.01）,respectively,among healthy elderly,MCI and AD,in that order.There were statistically significant among three groups.There was no statistically significant difference in IgG between healthy elderly and MCI （Z=0.64,P=0.52）.The level of IgG was higher in AD than in MCI （Z=3.26,P0.01） and healthy elderly （Z=3.22,P0.01）.The level of TH was higher in healthy elderly than in AD （Z=2.55,P0.05） and MCI （Z=2.95,P0.01）.There was no statistically significant difference in TH between MCI and AD （Z=0.18,P=0.86）.Conclusion：IgG may play an important role in differentiating healthy elderly,MCI and AD.Reduction in TH level could be a sign of cognitive impairment.