精神分裂症未治期及其影响因素研究

目的 了解精神分裂症患者首次正式开始治疗前的疾病未治疗期间(duration of untreated illness, DUI)和精神病未治疗期间(duration of untreated psychosis,DUP)及其影响因素.方法 应用诺丁汉起病症状量表(Nottingham onset schedule, NOS)调查上海市精神卫生中心的精神分裂症患者,共收集117例.同时,应用自编问卷对患者家属进行访谈,调查可能影响患者及时就诊的因素.结果 ① 精神分裂症患者DUI中位数是181天, DUP中位数是84天.② 首发非特异性精神症状以失眠和情绪障碍最为常见,出现频度超过50%;首发精神病性症状以幻听和被害妄想最为常见,出现频度达到47%.③ 影响患者就诊的主要因素是家属不认识精神病和患者不愿接受诊治.④ 以DUI中位数181天将患者区分为长DUI组和短DUI组,发现:长DUI组中回答家庭成员意见不一致是延误就诊因素的比例显著高于短DUI组(χ2=3.9,P<0.05).结论 精神分裂症患者从发病到开始治疗的疾病未治疗期间较长.影响DUI和DUP的因素是多方面的,值得进一步深入研究.

Duration of untreated illness and its influential factors in schizophrenia

Objective: To evaluate the duration of untreated illness(DUI),duration of untreated psychosis(DUP) and their influencing factors in schizophrenia.Methods: DUI and DUP were evaluated among 117 schizophrenia patients with Nottingham Onset Schedule(NOS).Their influencing factors were investigated by interviewing the relatives of patients with a self-made scale.Results:The median DUI and DUP were 181 days and 84 days respectively.The most common prodromal symptoms were insomnia and emotional disorders.The most ...