阿尔茨海默病患者的性激素水平研究

目的分析阿尔茨海默病(Alzheimer's disease,AD)患者血清性激素水平的改变,探讨性激素与AD发生的相关性,以及与AD患者的简易智能状态检查(MMSE)分值、病程关系的研究。方法采用1:1病例配对方法,对AD组与对照组进行MMSE检查,并用放射免疫法测定血清性激素水平。结果AD组雌二醇(E2)明显低于对照组,有显著性差异(P<0.05),女性AD组E2明显低于对照组,有显著性差异(P<0.05),男性AD组睾酮(T)明显低于对照组,有显著性差异(P<0.05)。AD组E2水平、男性AD组T水平与MMSE分值无明显相关性(P>0.05)。AD组E2水平与病程呈负相关,P<0.05。结论E2下降可能是AD发生的危险因素之一,特别是女性AD的高危因素。病程越长,E2水平越低。睾酮下降可能是男性AD发生的危险因素之一。

A correlation study beween sex hormone levels and Alzheimer' disease

Objective: To analyze the change of sex hormone levels in patients with Alzheimer's disease (AD), and to investigate the relevance that of sex hormone levels between patients with AD and normal controls, and to discuss the relation between the score of Mini-mental State Examination (MMSE) and sex hormone levels. Methods: It was a case-control study designed by the rate 1:1, and had MMSE was used to evaluate patients' mental state. Sex hormone in two groups was determined by radioimmunoassay. Results:Estradiol (E2) levels in patients with AD were significantly lower than that in normal controls (P<0.05). E2 levels in women with AD also had the same difference (P<0.05). Testosterone (T) levels in men with AD were significantly lower than that in normal controls (P<0.05). There is no strong correlation between E2 levels and the score of MMSE in patients with AD (P>0.05). There were no strong correlation between T levels and the score of MMSE in men with AD (P>0.05). There was a negative correlation between E2 levels and the course of disease in patients with AD (P<0.05).Conclusion:The decline of E2 levels may be a risk factor for AD, especially in women. The longer the course of disease, the lower the E2 level. The decline of testosterone may be one of the risk factors for men with AD.