细胞黏附分子CD99在人髓母细胞瘤中的表达及意义

目的 探讨细胞黏附分子CD99在人髓母细胞瘤组织中的表达特点及其临床意义。方法 采用免疫组化法检测107例髓母细胞瘤及15例瘤旁正常脑组织标本中CD99的表达。所有病人均随访至死亡或截止至2013年12月，随访时间为12~80个月，利用Kaplan-Meier生存曲线进行生存分析。结果 髓母细胞瘤CD99阳性表达率（57.94%，62/107）明显高于瘤周正常脑组织（0%，0/15；P<0.05）。CD99的表达水平与病人性别、年龄、肿瘤的病理组织学分型和分子亚型均无明显相关性（P>0.05）。CD99的高表达与髓母细胞瘤病人的预后呈显著负相关（P<0.05）。结论 CD99高表达与髓母细胞瘤预后显著相关，可作为预后判断的指标及治疗髓母细胞瘤潜在的新靶点。

Expression and clinical meanings of cell adhesion molecule CD99 in human medulloblastomas

Objective To investigate the expression and clinical meanings of cell adhesion molecule CD99 in human medulloblastomas (MB). Methods The levels of CD99 protein expression were determined by immunohistochemical technique in 107 MB samples and 15 peritumorous and normal cerebellum tissues samples. The relationship of CD99 expression with MB clinicopathological characteristics and prognosis in the patients with MB were analyzed statistically. Results The positive expression rate of CD99 (57.94%, 62/107) was significantly higher in MB tissues than that (0.00%, 0/15) in the normal cerebellum tissue (P<0.01). The expression of CD99 in MB tissues was not correlated with the patient's age and gender and tumorous histologic and molecular subtypes (P>0.05). Kaplan-Meier survival analysis suggested that the positive expression of CD99 in MB tissues was negatively correlated with the overall survival rate in the patients with MB (P<0.05). Conclusions High level of CD99 expression is significantly correlated with medulloblastoma progress and poor prognosis in the patients with MB, so it can be used as a novel biomarker and a new target for treating medulloblastomas and a novel index of predicting the prognosis in the patients with MB .