| 纳洛酮引起大鼠脑出血灶周围粘附分子表达减少 |
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| 引用本文： | 张守信,汪丙昂,肖文,李改丽,张红宾.纳洛酮引起大鼠脑出血灶周围粘附分子表达减少[J].中华神经外科疾病研究杂志,2005,4(5):437-439. |
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| 作者姓名： | 张守信 汪丙昂 肖文 李改丽 张红宾 |
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| 作者单位： | [1]解放军第三医院神经内科,陕西宝鸡721004 [2]解放军第三医院骨科,陕西宝鸡721004 |
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| 摘 要： | 目的探讨纳络酮(naloxone)是否可以减轻脑出血后继发性神经损伤.方法大鼠纹状体内注入胶原酶造成脑出血动物模型,采用免疫组织化学法观察纳络酮治疗组和生理盐水对照组脑出血后24 h出血区粘附分子的表达.结果生理盐水治疗组有很强的粘附分子免疫阳性;纳络酮治疗组粘附分子免疫阳性细胞数量显著低于生理盐水组(P＜0.05).结论纳络酮可能通过减轻脑出血后局部的炎性反应,从而起到脑保护作用.
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| 关 键 词： | 纳络酮 脑出血 粘附分子 |
| 文章编号： | 1671-2897（2005）04-437-03 |
| 收稿时间： | 2004-08-10 |
| 修稿时间： | 2005-02-18 |
Decreasing expression of adhesion molecules in peri-intracerebral hemorrhage fuci by naloxone |
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| ZHANG Shouxin ,WANG Bing'ang ,XIAO Wen ,LI Gaili ,ZHANG Hongbin.Decreasing expression of adhesion molecules in peri-intracerebral hemorrhage fuci by naloxone[J].Chinese Journal of Neurosurgical Disease Research,2005,4(5):437-439. |
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| Authors: | ZHANG Shouxin WANG Bing'ang XIAO Wen LI Gaili ZHANG Hongbin |
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| Institution: | ZHANG Shouxin 1,WANG Bing'ang 2,XIAO Wen 1,LI Gaili 1,ZHANG Hongbin 1 1 Department of Neurology, 2 Department of Orthopaedics,Third Hospital of PLA,BaoJi 721004,China |
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| Abstract: | Objective To study the effect of naloxone on decreasing the secondary injury of cerebral hemorrhage .Methods Collagenase was injected into the stratum of the rat to produce a bleeding. Immunohistochemical method was used to study the expression of adhesion molecules in the rat brain of naloxone group and normal saline control group 24 h after intracerebral hemorrhage.Results The adhesion molecule- immunoreactive cells were more densely distributed around the blood clot in control group 24 h after collagenase injection, and the number of adhesion molecules-positive cells decreased by naloxone, which made a significant difference to control group (P<0.05).Conclusion Naloxone may have the brain protective effects by relieving the inflammation in fuci after cerebral hemorrhage. |
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| Keywords: | Naloxone Cerebral hemorrhage Adhesion molecule |
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