立体定向神经干细胞移植治疗脑出血后遗症疗效分析

目的观察应用神经干细胞移植治疗脑出血后遗症的临床疗效。方法2000年6月至2006年12月我们对16例脑出血患者采用立体定向技术，选取病变侧基底节区作为靶点进行神经干细胞移植术，于治疗前、治疗后1月、6月进行神经功能评分，应用国际通用的功能独立性测量评定其运动及生活能力。结果接受神经干细胞移植的脑出血患者无严重手术并发症。手术后6个月内临床症状改善有效率达81．25％（13例／16例），本组16例术前FIM评分为90．21±2．32，术后1个月为92．76±1．89，术后6个月为96．37±3．83，差异有显著性意义。治疗1个月后功能独立性评分高于治疗前（P〈0．05），而治疗6个月后高于1个月（P〈0．05）。结论神经千细胞移植治疗可以一定程度地改善脑出血患者的后遗症，可提高脑出血患者的运动功能，提高患者生活质量，但其长期疗效仍需进一步观察。

Clinical transplantation of human neural stem cells in treatment of stroke sequela:report of 16 cases

Objective To investigate the effect of embryo neural stem cell transplantation （NSCT） in the clinical course of stroke. Methods Embryo neural stem cells were implanted into basal ganglia nuclei by using stereotactic technology in 16 patients with stroke from June 2000 to December 2006. The FIM （functional indepen dence measure） was adopted to evaluate the motor ability and self care ability of patients before and 1, 6 months after treatment. Results All patients who received NSCT benefited from the operation without serious complications. The effective rate （clinical symptom improving） was 81.25% （13 cases/16 cases）. FIM score before transplantation, 1 month and 6 months after transplantation were 90. 21 ± 2. 32, 92. 76 ± 1.89 and 96.37± 3.83, respectively. It was significantly higher 1 month after transplantation of neural stem cells than before transplantation and was significantly higher in 6 months than 1 month after transplantation. Conclusion Transplantation of neural stem cell can improve the sequela of stroke to some extent and improve the living quality of patients with stroke. But the long term effect should be further observed.