少突胶质细胞肿瘤的分子遗传学改变与其部位的相关性研究

目的 研究少突胶质细胞肿瘤分子遗传学改变和肿瘤部位的相关性.方法 回顾性地研究了105例胶质瘤.根据影像学资料记录每例肿瘤的部位,运用PCR-变性高效液相色谱技术检测肿瘤染色体1p和19q杂合性缺失的情况,用χ2检验和Fisher确切概率法评估肿瘤部位和分子遗传学特征之间的相关性.结果 位于非颞叶的少突胶质细胞肿瘤与位于颞叶的肿瘤相比,更倾向于具有1p和19q联合杂合性缺失,而星形细胞瘤的分子遗传学特征与其部位之间没有相关性.结论 不同分子亚型的少突胶质细胞肿瘤可能发生于不同的脑叶,即具有1p和19q联合杂合性缺失的肿瘤通常发生于非颞叶.

Correlations between molecular alterations and tumor location in oligodendroglial tumors

Objective To investigate the possible correlations between molecular alterations and tumor location in oligodendroglial tumors.Method A series of 105 gliomas were retrospectively reviewed.In each case,the radiologic picture and loss of heterozygosity(LOH)on chromosome 1p and 19q detected by PCR-denaturing high-performance liquid chromatography(DHPLC)were analyzed.The correlations between molecular profile and tumor location were made bv chi-square and Fisher's exact tests.Results Olig odendroglial tumors located in nontemporal lobes were significantly more likely to have combination of LOH 1P and LOH 19q than tumors arising in temporal lobes.In contrast to oligodendroglial tumors,we detected that there was no association between molecular alterations and location for diffuse astrocytomas.Conclusions We conclude that molecular subsets of oligodendroglial tumors may arise preferentially in certain lobes of the brain,with tumors having combination of LOH 1p and LOH 19q occurring most frequently in nontemporal lobes.