亚低温治疗对重型脑损伤急性期脑氧分压和脑温的影响

目的研究重型脑损伤急性期脑组织氧分压(P

Effect of mild hypothernia o n PbtO2 md BT of patiie nts with severe head injury

Objective To study the changes of partial pressure of braain tissue oxygen (PbtO2) and brain temperature (BT) in acute phase of patients with severe bead injury, and effect of mild hypothermie on PbtO2 and BT. Methods PbtO2 and BT of 18 patients with severe head injury were monitored, and hypothermia was induced within 20 hours of injury. Rewarming was begun on 1-7 days ( average 57.7 ± 28.4 hours) after the rectal temperature (BT)reached 31.5℃-34.9℃. Monitoringe of PbtO2 and BT were lasted for 1-5 days (average 54.8 ± 27.0 hours). According to Glasgow Outcome Scale(GOS),the prognosis of the patients was evaluated.Results Within 24 hours after severe head injury, PbtO2 was significantly lower (9.6 ± 6.8mmHg) than the normal value (16-40mmHg). BT was higher than RT. After treatment in mild hypothermia, eman PbtO2 raised to 28.7±8.8 mmHg during the first 24hours, and the PbtO2 1evel was maintained within the range of normal value at the third day after injury. The difference between BT and RT significarntly appeared in mild hypothemia. Hyperventilation (PaCO2≈25mmHg) induced and sensitive diagnostic method for the patients with severe head injury. It might become an important tool in our treatment regime for acute patients of severe head injury during hypothermia and hyperventilation.