小脑神经节胶质细胞瘤11例分析

目的 探讨小脑神经节胶质细胞瘤的临床特点、治疗和预后.方法 对11例经手术和病理证实的小脑神经节胶质细胞瘤患者的临床资料进行回顾性分析.结果 11例患者中,位于小脑半球6例,小脑蚓部5例.其平均发病年龄为25岁,主要临床表现为颅内压增高和共济失调.11例肿瘤中镜下全切除6例,近全切除5例.除1例术后出现脑膜炎外无其他手术并发症.术后无死亡病例.10例患者得到随访,平均随访3年,9例恢复正常工作,1例死于糖尿病并发症,未见肿瘤复发.结论 小脑神经节胶质细胞瘤术前诊断需根据病史、神经影像学检查综合分析.明确诊断需要组织病理学检查.手术是主要的治疗方法,可取得良好的临床效果.

Analysis on 11 cases of cerebellar gangliogliomas

Objective Ganglioglioma ( GG) is a less common primary neoplastic disease of the central nervous system that is typically located supratentorially. The objective of the study is to discuss the clinical characteristics, microsurgical treatment and prognosis of the cerebellar GGs. Method The hospital data of 11 patients who had undergone microsurgery and were pathologically diagnosed as cerebellar GGs were reviewed. Results Among 11 patients, 6 located in the cerebellum and 5 located in thevermiform process of cerebellum respectively. The main clinical presentations were intracranial hypertension and ataxia. The mean age at presentation was 25 years. The operations consisted of total resection in six, subtotal resection in 5. There was no increased neurological deficits except for one meningitis, and no postoperative death. Ten patients were followed up with a mean of 3 years, of which 9 lived a normal life expect for one patient died of diabetes mellitus complication. There was one patient with recurrent tumors in the series. Conclusions Preoperative diagnosis of cerebellar GGs may be presumed on the basis of case history and neuroimaging examinations. Its precise diagnosis mainly depends on histopathology. Surgical resection is the principal treatment for cerebellar GGs and can get the good prognosis.