| 首发未服药精神分裂症患者血浆非酶抗氧化物浓度分析 |
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| 引用本文： | 李艳丽,谭云龙,杨甫德,朱凤艳,王宁,陈松,王志仁,周东丰.首发未服药精神分裂症患者血浆非酶抗氧化物浓度分析[J].中国神经精神疾病杂志,2011,37(2). |
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| 作者姓名： | 李艳丽 谭云龙 杨甫德 朱凤艳 王宁 陈松 王志仁 周东丰 |
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| 作者单位： | 1. 北京回龙观医院精神医学研究中心,北京,100096
2. 北京大学第六医院 |
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| 基金项目： | 北京市优秀人才培养基金项目(编号:20061D0301400098) |
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| 摘 要： | 目的探讨首发未服药精神分裂症患者血浆非酶抗氧化物水平及其与临床特征间的关系。方法测定55例首发未服用抗精神病药精神分裂症患者和42名正常对照的血浆非酶抗氧化物水平,包括白蛋白、总胆红素浓度和尿酸浓度;采用阳性和阴性症状量表(positive and negative symptoms scale,PANSS)评定精神症状。结果患者组血浆白蛋白和尿酸浓度明显低于对照组(44.72±3.42)g/Lvs(46.70±3.43)g/L,(3.11±1.00)×102μmoL/Lvs(5.00±1.01)×102μmoL/L,P均小于0.05];以阳性症状为主的患者血浆总胆红素浓度明显高于以阴性症状为主的患者(12.48±3.86)μmoL/L vs(10.27±1.78)μmoL/L,P=0.04];男性患者尿酸浓度明显高于女性患者(3.54±1.21)×102μmoL/L vs(2.88±0.76)×102μmoL/L,P=0.01];对照组男女性之间上述3个指标的差异均无统计学意义(P>0.05);相关分析仅发现对照组血浆白蛋白、尿酸与年龄相关(r=-0.39,P=0.01;r=-0.40,P=0.01)...
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| 关 键 词： | 精神分裂症 抗氧化物 白蛋白 总胆红素 尿酸 |
The study on plasma non-enzyme antioxidants levels in the first-episode medication-free patients with schizophrenia |
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| LI Yanli,TAN Yunlong,YANG Fude,ZHU Fengyan,WANG Ning,CHEN Song,WANG Zhiren,ZHOU Dongfeng.The study on plasma non-enzyme antioxidants levels in the first-episode medication-free patients with schizophrenia[J].Chinese Journal of Nervous and Mental Diseases,2011,37(2). |
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| Authors: | LI Yanli TAN Yunlong YANG Fude ZHU Fengyan WANG Ning CHEN Song WANG Zhiren ZHOU Dongfeng |
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| Institution: | LI Yanli,TAN Yunlong,YANG Fude,ZHU Fengyan,WANG Ning,CHEN Song,WANG Zhiren,ZHOU Dongfeng.Division of Biopsychiatry Research,Beijing Huilongguan Hospital,Chang-ping District.Beijing 100096.China. |
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| Abstract: | Objective To investigatehe the plasma non-enzyme antioxidants levels and their correlations with clinical traits in first-episode medication-free patients with schizophrenia. MethodsThe plasma antioxidants levels included albumin,bilirubin and uric acid levels were examined in 55 first-episode medication-free schizophrenic patients and 42 healthy controls.Psychopathological symptoms were assessed by using the positive and negative symptom scale(PANSS). ResultsThe plasma albumin and uric acid levels were sig... |
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| Keywords: | Schizophrenia Antioxidant Albumin Bilirubin Uric acid |
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