| 男性精神分裂症患者前额叶质子波谱特点及其与执行功能的关系 |
| |
| 引用本文： | 段惠峰,甘景梨,杨家明,高存友,张东卫,祝希泉,蒋战魁,史振娟.男性精神分裂症患者前额叶质子波谱特点及其与执行功能的关系[J].中国神经精神疾病杂志,2010,36(3). |
| |
| 作者姓名： | 段惠峰 甘景梨 杨家明 高存友 张东卫 祝希泉 蒋战魁 史振娟 |
| |
| 作者单位： | 1. 解放军第91中心医院全军精神疾病防治中心,焦作,454003
2. 解放军第91中心医院影像中心 |
| |
| 摘 要： | 目的探讨男性精神分裂症患者前额叶氢质子磁共振波谱(proton magnetic resonance spectrosco-py,1H-MRS)的特点及与执行功能的关系。方法纳入26例7d内未使用抗精神病药物及影响脑内乙酰胆碱神经递质药物的男性精神分裂症患者及28名男性正常对照。两组在入组24h内采用多体素1H-MRS检测前额叶生化代谢物N-乙酰基天门冬氨酸(NAA)、胆碱复合物(Cho)与肌酸复合物(Cr),完成NAA/Cr值、Cho/Cr值和NAA/(Cho+Cr)值的计算,同时进行威斯康星卡片分类测验(Wisconsin Card Sorting Test,WCST)评定受试者的执行功能。结果患者组左侧前额叶NAA/Cr值(1.40±0.34)低于对照组(1.69±0.31),差异有统计学意义(t=2.93,P0.01)。患者组WCST的错误应答数、持续应答数、持续错误数均明显高于对照组(t分别为2.32、2.25、2.40,P均小于0.05),分类数和概念化水平应答数均明显低于对照组(t=2.91,P0.01;t=2.46,P0.05)。患者组左侧前额叶NAA/Cr值与错误应答数、持续错误数呈正相关(r=0.45,P0.05;r=0.47,P0.05),与分类数、概念化水平应答数呈负相关(r=-0.54,P0.01;r=-0.56,P0.01)。结论男性精神分裂症患者左侧前额叶可能存在神经元功能和(或)结构异常,这可能是引起额叶执行功能障碍的原因。
|
| 关 键 词： | 精神分裂症 磁共振波谱 威斯康星卡片分类测验 前额叶 |
A ~1H-MRS study of the prefrontal lobe in male schizophrenics |
| |
| DUAN Huifeng,GAN Jingli,YANG Jiaming,GAO Cunyou,ZHANG Dongwei,ZHU Xiquan,JIANG Zhankui,SHI Zhenjuan.A ~1H-MRS study of the prefrontal lobe in male schizophrenics[J].Chinese Journal of Nervous and Mental Diseases,2010,36(3). |
| |
| Authors: | DUAN Huifeng GAN Jingli YANG Jiaming GAO Cunyou ZHANG Dongwei ZHU Xiquan JIANG Zhankui SHI Zhenjuan |
| |
| Institution: | DUAN Huifeng,GAN Jingli,YANG Jiaming,GAO Cunyou,ZHANG Dongwei,ZHU Xiquan,JIANG Zhankui,SHI Zhenjuan.People\'s Liberation Army 91st Central Hospital,Gongye Road,Jiaozuo 454003 China |
| |
| Abstract: | Objective To identify the metabolic alterations in the prefrontal lobe in male patients with schizophrenia by proton magnetic resonance spectroscopy(1H-MRS),and to study the relationship between metabolic alterations and executive function.Methods The study was conducted in 26 male schizophrenics with medicine-free for at least 7 days and 28 normal controls.A multi-voxel 1H-MRS on the prefrontal lobe was performed in all the subjects within 24 hours of admission.Wisconsin Card Sorting Test(WCST)was used to ... |
| |
| Keywords: | Schizophrenia Proton magnetic resonace spectroscopy Wisconsin card sorting test Prefrontal lobe |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
