精神分裂症认知功能状况及影响因素

目的　探讨精神分裂症认知功能的状况及影响因素。方法　对 36例精神分裂症患者在治疗前、治疗后 6周作神经心理测验和阴性及阳性症状量表 (PANSS)、临床总体印象量表 (CGI)、副反应量表 (TESS)、锥体外系副反应量表 (RSESE)的评定 ,并以 36名健康人进行对照。结果　精神分裂症患者与正常对照组比较 ,两组在知识、算术、数字符号、数字广度 (顺、逆 )、木块拼图、瞬时逻辑记忆、视觉再生即刻和延迟、STROOPC W正确数、词汇流畅、TOH总分 ,计划时间、延迟逻辑记忆、WCST所有指标有显著差异 (P <0 0 5 )。阳性症状量表减分率与视觉再生及WCST分类个数成绩的提高呈显著正相关。而阴性症状量表减分率与瞬时逻辑记忆成绩的提高呈显著正相关。安坦的剂量与木块拼图、瞬时逻辑记忆及WCST分类个数 3项成绩的提高呈显著负相关。安定的药量与算术、视觉再生、汉诺塔总分的改善呈显著负相关。结论　精神分裂症患者存在广泛的认知功能的损害 ,其认知功能可能受到阳性症状、阴性症状、安坦及安定药量的影响。

A study on cognitive functioning in schizophrenics

Objective The study aimed to evaluate the effects on cognitive functioning in schizophrenics. Methods Forty Patients with schizophrenia were measured on neuropsychological tests and PANSS. CGI, TESS and RSESE rating scales before treatment and in the sixth week after therapy. Tirty six healthy individuals in control group were given a same neuropsychologicla assessment. Results The results of comparison in neuropsychological measurement between schizophrenia group and normal control group is that there are significant difference in those tests such as knowledge\, arithmetic\, digital sign\, digital span\, game of puzzle\, logical memory visual reproduction\, correct number of STROOPC\, verbal fluency\, score and plan time of tower of Hanoi and WCST ( P<0.05 ). Marked statistical significance on partial correlations was found between improvement of positive symptom and increase of visual reproduction and classificatory piece of WCST(positive correlation), tween negative symptom and logical memory immediately (positive correlation), tween dosage of artane and game of puzzle\, logical memory immediately and classificatory piece of WCST(negative correlation), tween dosage of diazepam and arithmetic\, visual reproduction and score of tower of Hanoi (negative correlation). Conclusions Cognitive function is markedly imparied in most schizophrenics. Positive symptom, negative symptom and dosage of artane and diazepam possibly play some action during the therapy of cognitive functioning in schizophrenics.