| 胶质瘤1p/19q联合缺失特征分析 |
| |
| 引用本文： | 赛克,王芳,牟永告,张湘衡,柯超,杨群英,邵建永,陈忠平. 胶质瘤1p/19q联合缺失特征分析[J]. 中国神经精神疾病杂志, 2011, 37(8) |
| |
| 作者姓名： | 赛克 王芳 牟永告 张湘衡 柯超 杨群英 邵建永 陈忠平 |
| |
| 作者单位： | 1. 华南肿瘤学国家重点实验室中山大学肿瘤防治中心神经外科,广州,510060
2. 华南肿瘤学国家重点实验室中山大学肿瘤防治中心病理科,广州,510060 |
| |
| 摘 要： | 目的 研究胶质瘤中1p/19q联合缺失与患者临床特征及O6-甲基鸟嘌呤-DNA甲基转移酶(O6-methylguanine-DNA methyltransferase,MGMT)表达的关系.方法 使用荧光原位杂交技术,对中山大学附属肿瘤医院2009年3月至2011年3月的63例手术确诊胶质瘤标本进行1p/19q联合缺失检测,利用统计学方法分析1p/19q联合缺失患者与无联合缺失患者在性别、年龄、部位、病理类型及MGMT表达状态是否有差异.结果 全组63例患者,男38例,女25例,年龄(41.7 ± 15.3)岁.其中,16例(25.4%)存在1p/19q联合缺失.1p/19q联合缺失患者与无联合缺失患者在性别、年龄及肿瘤部位间的差异无统计学意义.各病理类型1p/19q联合缺失的比例从高到低依次为少突胶质细胞瘤(9/16)、间变性少突胶质细胞瘤(3/8)、星形细胞瘤(2/10)、间变性星形细胞瘤(1/6)及胶质母细胞瘤(1/21),其差异有统计学意义(P ＜ 0.01).在全组63例胶质瘤及25例含少突成分胶质瘤中,MGMT阳性肿瘤1p/19q联合缺失比例与MGMT阴性组间的差异皆无统计学意义.结论 1p/19q联合缺失主要与胶质瘤的病理类型有关,含少突成分胶质瘤中1p/19q联合缺失比例较高.1p/19q联合缺失可作为少突胶质细胞瘤病理诊断的重要参考指标.
|
| 关 键 词： | 胶质瘤 1p/19q联合缺失 MGMT 病理 |
Analysis of 1p/19q Codeletion in Gliomas: Report of 63 Cases |
| |
| SAI Ke,WANG Fang,MOU Yong-gao,ZHANG Xiangheng,KE Chao,YANG Qunying,SHAO Jianyong,CHEN Zhongping. Analysis of 1p/19q Codeletion in Gliomas: Report of 63 Cases[J]. Chinese Journal of Nervous and Mental Diseases, 2011, 37(8) |
| |
| Authors: | SAI Ke WANG Fang MOU Yong-gao ZHANG Xiangheng KE Chao YANG Qunying SHAO Jianyong CHEN Zhongping |
| |
| Affiliation: | SAI Ke,WANG Fang,MOU Yong-gao,ZHANG Xiangheng,KE Chao,YANG Qunying,SHAO Jianyong,CHEN Zhongping.Department of Neurosurgery,Sun Yat-sen University Cancer Center,651 Dongfeng Road East,Guangzhou 510060. |
| |
| Abstract: | Objective To detect 1p/19q codeletion in patients with gliomas and investigate the relationship between 1p/19q codeletion and other clinical features including age,sex,location of tumors and the expression of O6-methylguanine-DNA methyltransferase(MGMT).Methods Fluorescence in situ hybridization(FISH) was used to detect 1p/19q codeletion in 63 cases with pathologically confirmed gliomas in Sun Yat-sen University from March 2009 to March.Clinical data were retrospectively reviewed.The relationship between 1p... |
| |
| Keywords: | Glioma 1p/19q codeletion MGMT Pathology |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
