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| 纤维追踪技术探索精神分裂症患者及其同胞的脑白质完整性 | |
| 引用本文： | 郝以辉,高金松,张会然,欧阳萱,刘海洪,李幼辉,宋学勤,刘哲宁.纤维追踪技术探索精神分裂症患者及其同胞的脑白质完整性[J].中国神经精神疾病杂志,2011,37(12). |
| 作者姓名： | 郝以辉 高金松 张会然 欧阳萱 刘海洪 李幼辉 宋学勤 刘哲宁 |
| 作者单位： | 1. 郑州大学第一附属医院精神医学科,郑州,450052 2. 中南大学精神卫生研究所 3. 中南大学湘雅医院 |
| 基金项目： | 国家科技部973项目(编号:2007CB512300); 国家自然科学基金(编号:81071092,30971058) |
| 摘 要： | 目的 探索精神分裂症患者及其健康同胞是否具有相似的脑白质完整性受损.从而为该异常是否为精神分裂症的易感性生物学特征提供依据.方法 利用基于像素的全脑分析方法比较精神分裂症患者30例及其健康同胞30名和正常对照30名的脑白质密度,将组间有差异的区域作为感兴趣区,利用纤维追踪技术重建穿过这些区域的白质纤维柬,比较三组之间纤维束的各向异性值(FA).结果 精神分裂症患者组及其同胞组左侧前额叶的各向异性低于正常对照组(0.296±0.030),(0.302±0.030),(0.326±0.026),P<0.05],两组的胼胝体膝部的各向异性也低于正常对照组(0.560±0.031),(0.568 ±0.025),(0.581 ±0.028),P<0.05],但患者组与同胞组之间的上述差异均无统计学意义(P>0.05).结论 左侧前额叶和胼胝体膝部白质完整性受损可能是精神分裂症的易感性生物学特征. |
| 关 键 词： | 精神分裂症 健康同胞 纤维追踪 白质完整性 |
MRI fiber tracking study on the white matter integrity in schizophrenia and their siblings |
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| HAO Yihui,GAO Jinsong,ZHANG Huiran,OUYANG Xuan,LIU Haihong,LI Youhui,SONG Xueqin,LIU Zhening.MRI fiber tracking study on the white matter integrity in schizophrenia and their siblings[J].Chinese Journal of Nervous and Mental Diseases,2011,37(12). | |
| Authors: | HAO Yihui GAO Jinsong ZHANG Huiran OUYANG Xuan LIU Haihong LI Youhui SONG Xueqin LIU Zhening |
| Institution: | HAO Yihui,GAO Jinsong,ZHANG Huiran,OUYANG Xuan,LIU Haihong,LI Youhui,SONG Xueqin,LIU Zhening.Department of Psychiatry of the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China |
| Abstract: | Objective To identify whether the integrity of brain white matter is abnormal in schizophrenia patients and their unaffected siblings.Methods White matter density was compared among schizophrenic patients,their unaffected siblings and healthy controls using voxel-based morphometry and the brain regions showing significant difference among groups were defined as the region of interest(ROI).Fiber tracking was then used to reconstruct the white matter fiber within ROI and then the fractional anisotropy(FA) was... |
| Keywords: | Schizophrenia Unaffected siblings Fiber tracking White matter integrity |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |