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皮肤交感反应在糖尿病周围神经病早期诊断中的价值
引用本文:贾志荣,石昕,黄一宁,孙相如.皮肤交感反应在糖尿病周围神经病早期诊断中的价值[J].中华神经科杂志,2003,36(3):188-190.
作者姓名:贾志荣  石昕  黄一宁  孙相如
作者单位:100034,北京大学第一医院神经内科
摘    要:目的 探讨皮肤交感反应 (SSR)与糖尿病自主神经系统交感神经病变的关系 ,为糖尿病自主神经系统病变的早期诊断提供客观依据。方法 对 80例糖尿病患者及 30名健康人四肢进行SSR测定 ,对两组SSR各波潜伏期及波幅的均值行t检验。结果 两组SSR的起始潜伏期、N波、P波潜伏期比较差异有显著意义 (P <0 0 0 1) ;N波波幅、P波波幅差异无显著意义 (P >0 0 5 )。健康对照组全部可引出SSR ,而糖尿病组仅 2例患者四肢可正常引出SSR ,78例 (97 5 % )患者至少有一肢SSR潜伏期异常。结论 SSR为糖尿病性自主神经系统交感神经病变的早期诊断提供了新的方法和客观依据 ,可发现糖尿病自主神经系统交感神经纤维的早期病变。

关 键 词:皮肤交感反应  糖尿病周围神经病  早期诊断  电生理学  交感神经功能
修稿时间:2003年2月9日

The value of sympathetic skin response for early diagnosis of diabetic neuropathy
JIA Zhi-rong,SHI Xin,HUANG Yi-ning,et al..The value of sympathetic skin response for early diagnosis of diabetic neuropathy[J].Chinese Journal of Neurology,2003,36(3):188-190.
Authors:JIA Zhi-rong  SHI Xin  HUANG Yi-ning  
Institution:JIA Zhi-rong,SHI Xin,HUANG Yi-ning,et al. Department of Neurology,the First Hospital,Peking University,Beijing 100034,China
Abstract:Objective To study the association between sympathetic skin response (SSR) and diabetic neuropathy,and explore its use as the objective base for its early diagnosis. Methods The latencies and amplitudes of the initiation,waves N and P in SSR of the extremities in 80 diabetic patients and 30 healthy controls were determined using electrophysiological measurements. Results The latencies of the initiation,waves N and P of SSR test were prolonged significantly in the diabetic patients as compared to the controls ( P <0.001),while there was no significant difference in the amplitudes ( P >0.05). All but two patients (97.5%) demonstrated abnormal SSR in at least one limb. Seven patients (8.8%) had no responses in SSR in both the feet and hands. The frequency of abnormality in the latency of initiation and waves N and P was 86.9%(139/160)in the upper limbs,and 89.4%(143/160)in the lower limbs. Conclusions The SSR can detect the early dysfunction of the small sympathetic fibers in diabetes millitus and may be a useful electrophysiologic testing for the early diagnosis of diabetic neuropathy.
Keywords:Diabetic neuropathies  Peripheral nervous system disease  Electrophysiology  Sympathetic nervous system
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