X-刀单次与分次治疗垂体腺瘤的疗效分析

目的探讨垂体腺瘤行x-刀单次治疗与分次治疗后疗效与并发症的差异。方法回顾性分析121例经x-刀治疗的垂体腺瘤病人的临床资料,根据治疗方式不同分为单次治疗组（70例）与分次治疗组（51例）,比较两组疗效及并发症发生率的差异。结果治疗后总体肿瘤控制率为95．9％,其中单次治疗组肿瘤控制67例（95．7％）,分次治疗组肿瘤控制49例（96．1％）;治疗后激素水平控制率为38．0％,其中单次治疗组激素水平控制28例（40．0％）,分次治疗组激素水平控制18例（35．3％）;两组肿瘤控制和激素水平控制差异均无统计学意义（P〉0．05）。而治疗后两组1、2、3级并发症发生率差异均有统计学意义（P〈0．05）。结论适当的治疗间隔时间的分次治疗是降低并发症的可靠方法。

Efficacy analysis of single and fractionated therapy by X-knife for pituitary adenomas

Objective To study the differences in efficacy and complications between single and fractionated therapy by X-knife for pituitary adenomas. Methods Clinical data of 121 patients with pituitary adenomas treated by X-knife were analyzed retrospectively, and divided into single therapy group （n = 70） and fractionated therapy group （n = 51） according to the treatment methods. The differences in efficacy and complication rates between two groups were compared. Results Overall tumor control rate was 95.9% after treatment, including 67 patients （95.7%） in single therapy group and 49 （96.1%） in fractionated therapy group. The control rate of hormone level after treatment was 38.0%, including 28 patients （40.0%） in single therapy group and 18 （35.3%） in fractionated therapy group. There were no statistically significant differences in control rates of tumor and hormone level between the two groups （P 〉 0.05）, while there was a statistically significant difference in the complication incidence of grades 1, 2, 3 between the two groups （P 〈 0.05）. Conclusion Fractionated therapy with proper treatment intervals is a reliable method for reducing the complications of pituitary adenomas.