皮电生物反馈治疗卒中后抑郁的对照研究

目的 通过对卒中后抑郁（post-stroke depression，PSD）患者随机分组进行皮电生物反馈（galvanic skin response，GSR）及假反馈训练，比较训练前后抑郁症状及生理指标的变化，探讨GSR生物反馈对 PSD患者的疗效。 方法 24例卒PSD患者随机分为GSR反馈组（11例）和对照组（13例），均给予常规康复治疗和药物治 疗，反馈组在此基础上接受GSR生物反馈治疗，每次40 mi n，每周3次，共4周，对照组仅使用电脑开展 放松治疗而没有反馈信号。在治疗前后采用汉密尔顿抑郁量表（Hamilton depression scale，HAMD）进行 评估，并在安静状态下进行各生理指标的采集，比较训练前后抑郁症状及生理指标的变化。 结果 GSR组经训练后，HAMD量表焦虑躯体化症状（P =0.034）、认知症状（P =0.019）及抑郁总分 （P =0.011）与对照组比较有显著改善。GSR组经训练后，生理指标皮电明显减小（ 0.94±2.38）μV vs （0.59±0.33）μV，P =0.023]。 结论 GSR生物反馈能改善卒中后抑郁患者的抑郁症状及生理指标。

A Control Study on the Effects of Galvanic Skin Response Biofeedback Therapy in Patients of Post-stroke Depression

Objective To explore the effect of the galvanic skin response (GSR) biofeedback treatment therapy on mood of patients with post-stroke depression (PSD) through randomized GSR and false biofeedback training and comparison of changes of depression symptoms and physical signs before and after training. Methods A total of 24 patients with post-stroke depression were randomly divided into GSR feedback group (N=11) and control group (N=13). All the patients were given routine rehabilitation therapy and medication therapy, while patients in GSR feedback group were given additional galvanic skin response biofeedback therapy and control group patients carried out the experiment by the computer software without feedback signal (40 minutes 3 times a week for 4 weeks). The effects were evaluated by Hamilton Depression Scale (HAMD) before and after treatment respectively. The changes of physiological indicators were tracked by using a multi-channel biofeedback instrument during baseline and pressure stress tests before and after treatment respectively. Results After treatment, the anxiety and somatization symptoms score (P=0.034), cognitive score (P=0.019) and depression total score (P=0.011) of GSR feedback group in the HAMD were signiifcantly improved compared with the control group. After treatment, the value of galvanic skin response in GSR group was obviously reduced (0.94±2.38]μVvs 0.59±0.33]μV,P=0.023). Conclusion GSR biofeedback can improve mood symptoms and physiological indicators of PSD.