血管性认知功能障碍与同型半胱氨酸、颈动脉粥样硬化的关系

目的探讨血管性认知障碍(vascular congnitive impairment,VCI)与血清同型半胱氨酸(homocysteine,Hcy)及颈动脉粥样硬化的关系。方法选取2007年2月至2009年7月的缺血性卒中患者147例,依据卒中后3个月的认知评定结果及相应的诊断标准分为VCI组和认知正常组(对照组),所有病例均进行颈动脉超声检测,并测定两组患者的血清Hcy,并对两组的神经心理检查结果进行比较分析。结果 VCI组患者的血浆Hcy水平明显高于对照组,两组间的差异具有统计学意义(P0.05),按颈动脉粥样硬化程度分组后发现颈动脉内膜中层厚度(intima—mediathickness,IMT)1.0mm组简易精神状态量表(mini-mental state examination,MMSE)得分高于IMT1.0mm组(P0.05)。结论 VCI与血清Hcy及颈动脉粥样硬化密切相关。

Relationship between Vascular Cognitive Impairment with Serum Homocysteine and Carotid Artherosclerosis

Objective To investigate the relationship between vascular cognitive impairment with serum homocysteine（Hcy）and carotid artherosclerosis. Methods One hundred and forty-seven cerebral infarction patients from February 2007 to July 2009 were selected. According to the Neuropsychologic examination, they were divided into two groups： vascular congnitive impairment（VCI） group and normal cognitive group. Ultrasonography of carotid artery were performed in all patients. The concentration of serum Hcy were tested in two groups. The Neuropsychologic examination of both groups were compared. Results The concentration of Hcyin vascular cognitive impairment group was higher than that of control group（P〈0.05）. The scores of MMSE in the intima-media thickness（IMT）〈1.0mm group were higher than that in the IMT〉1.0mm group（P〈0.05）. Conclusion Vascular cognitive impairment was related to serum Hcy and Carotid artherosclerosis.