Hyperhomocysteinemia in dementia |
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| Authors: | F Leblhuber J Walli E Artner-Dworzak K Vrecko B Widner G Reibnegger D Fuchs |
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| Institution: | (1) Department of Gerontology, Landesnervenklinik Wagner Jauregg, Linz,,;(2) Institute of Medical Chemistry and Biochemistry, University of Innsbruck, and,;(3) Institute of Medical Chemistry, University of Graz, Austria, AT |
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| Abstract: | Summary. Hyperhomocysteinemia is a strong risk factor for atherosclerotic vascular disease, and elevated serum homocysteine is correlated
with vitamin B deficiency. In this pilot study, significantly elevated homocysteine levels were found in patients with Alzheimer's
disease as well as in patients with vascular dementia, probably indicating similar pathophysiological pathways. We found significant
correlations between low folic acid concentrations as well as high homocysteine concentrations and cognitive decline. Supplementation
with folic acid may be an inexpensive way to reduce elevated homocysteine levels in demented patients.
Received March 20, 2000; accepted June 30, 2000 |
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| Keywords: | : Homocysteine dementia Alzheimer's disease vascular dementia folic acid |
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