Functional gene variants of the serotonin-synthesizing enzyme tryptophan hydroxylase 2 in migraine |
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| Authors: | Martin Marziniak Gregor Kuhlenbäumer Claudia Sommer Rainald Mössner |
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| Institution: | 1.Department of Neurology,University of Münster,Münster,Germany;2.Department of Neurology,University of Saarland,Homburg,Germany;3.Department of Neurology,University of Würzburg,Würzburg,Germany;4.Department of Psychiatry and Psychotherapy,University of Würzburg,Würzburg,Germany;5.Department of Psychiatry and Psychotherapy,University of Bonn,Bonn,Germany;6.Leibniz-Institute for Atherosclerosis Research,Münster,Germany;7.Klinik und Poliklinik für Neurologie,Universit?tsklinikum Münster,Münster,Germany |
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| Abstract: | Serotonin (5-HT) plays an important role in the pathophysiology of migraine. Tryptophan hydroxylase 2 (TPH2) is the rate-limiting
enzyme in the biosynthesis of 5-HT in the brain and is therefore a major factor in the availability of 5-HT and its rate of
production. We hypothesized that functional TPH2 gene variants are associated with migraine. In a case–control study approach,
two proven functional and two putatively functional variants of the TPH2 gene were investigated in 266 migraine patients and
153 controls. Genotype, allele, and haplotype frequencies did not differ between healthy subjects and migraineurs. A subgroup
analysis for the occurrence of aura or clinical characteristics, including the number of attacks, did not reveal a positive
association for the investigated polymorphisms. Our data argue against a major influence of the TPH2 gene promoter region
in migraine. |
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| Keywords: | Tryptophan hydroxylase 2 Polymorphism Haplotype analysis Migraine |
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