|
|||||
|
|
Behavioral and biochemical stereoselectivity of sigma opiate/PCP receptors |
|
| Authors: | Stephen R Zukin Kathleen T Brady Barbara L Slifer Robert L Balster |
| Abstract: | The relative potencies of the stereoisomers of ketamine, N-allylnormetazocine and cyclazocine were determined at μ opiate and σ opiate/phenycyclidine (PCP) receptors in vitro in rat brain homogenates, as well as in a discriminative stimulus behavioral paradigm in rats trained to discriminate PCP from saline. In all cases the in vivo and in vitro data were in agreement. The (+)-isomers of N-allylnormetazocine and cyclazocine are highly specific sigma opiate/PCP ligands. |
| Keywords: | phencyclidine ketamine sigma opiate N-allylnormetazocine cyclazocine opiate receptors phencyclidine receptors |
| 本文献已被 ScienceDirect 等数据库收录！ | |