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Phase changes induced by ketamine in the vertical vestibulo-ocular reflex in the rabbit
Authors:M Favilla  B Ghelarducci  A La Noce  A Starita
Abstract:The effect of ketamine has been tested on the phase of the vertical vestibulo-ocular reflex of rabbits sinusoidally oscillated at various frequencies. A significant phase lag, predominantly affecting the macular component of the reflex, was observed. This action resembles that induced by Nembutal in the same preparation. A specific action of ketamine on synaptic transmission is suggested. Erroneous phase relationship between natural stimuli and responses can be obtained in experiments employing ketamine.
Keywords:ketamine anesthesia  Nembutal anesthesia  awake preparations  vestibulo-ocular reflex  dynamic vestibular stimulation
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