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Diffuse noxious inhibitory controls (DNIC) in the rat with or without pCPA pretreatment
Authors:Anthony H Dickenson  Jean-Paul Rivot  Athamane Chaouch  Jean-Marie Besson  Daniel Le Bars  
Institution:Unite´de Recherche de Neurophysiologie Pharmacologique de l''I.N.S.E.R.M. (U. 161), 2, rue d''Ale´sia, 75014 Paris, France
Abstract:Diffuse Noxious Inhibitory Controls (DNIC) were investigated in anaesthetized intact rats, with or without p-chlorophenylalanin (pCPA) pretreatment. Dorsal horn convergent neurones responding to both noxious and non-noxious stimuli applied to their excitatory receptive field located on the distal part of the hindlimb, were recorded in the lumbar spinal cord. These cells received Aα and C fibre inputs as shown by electrical stimulation of their receptive field.In control animals, the evoked responses to C fibre inputs coulb be strongly inhibited by various noxious stimuli applied to widespread areas of the body: the inhibitory effects induced by intraperitoneal administration of bradykinin, pinch applied to the tail or muzzle and noxious heat applied to the tail were of 77%, 87%, 83% and 61% respectively. Long-lasting post-effects were seen in most cases after cessation of the application of the conditioning stimulus.Pretreatment with pCPA (300 mg/kg, i.p., 3 days) resulted in a strong reduction of DNIC. The inhibitory effects induced by intraperitoneal administration of bradykinin, pinch applied to the tail or muzzle and noxious heat applied to the tail were reduced by 47%, 63%, 87% and 63%, respectively. The post-effects were also reduced both in terms of magnitude and duration.These results strongly suggest that serotonergic pathways are partially involved in
Keywords:dorsal horn  diffuse noxious inhibitory controls  serotonin  pain
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