口服糖皮质激素在慢性鼻窦炎伴鼻息肉围手术期的应用现状

鼻内镜鼻窦手术(ESS)已成为外科治疗慢性鼻窦炎伴鼻息肉(CRSwNP)的“金标准”,鼻内镜鼻窦手术围手术期管理对手术效果有重要影响。目前口服糖皮质激素因其抗炎和免疫抑制作用已作为ESS围术期辅助用药以增强手术效果,但在其剂量剂型及疗效等方面仍存在争议。回顾近年来研究口服糖皮质激素与CRSwNP围手术期疗效的相关文献,对口服糖皮质激素在围手术期的效果及治疗策略进行综述,以求提供更多的治疗选择和研究方向。

Application status of oral corticosteroids during the perioperative period of chronic rhinosinusitis with nasal polyps

Endoscopic sinus surgery (ESS) has become the “gold standard” for the surgical treatment of chronic rhinosinusitis with nasal polyps (CRSwNP). The perioperative management of ESS has an important influence on the results of surgery. At present, oral glucocorticoids have been used as ESS perioperative adjuvant drugs to enhance the surgical effect due to their anti inflammatory and immunosuppressive effects. However, there are still controversies related to their dosage form and efficacy. This article reviews the recent studies on oral glucocorticoids and CRSwNP related literature on perioperative efficacy. The effects and treatment strategies of oral glucocorticoids during the perioperative period have been reviewed to provide more treatment options and research directions.