头脉冲试验与头脉冲抑制试验参数相关性分析

目的验证头脉冲试验（HIMP）和头脉冲抑制试验（SHIMP）在前庭眼动反射中的互补效应。方法选择前庭上神经炎患者33例，健康成人10例（20耳），对前庭上神经炎患者患侧和健康成人左右侧HIMP和SHIMP增益、扫视潜伏期、扫视波振幅及显性扫视产生百分比进行匹配分析，比较HIMP和SHIMP各项参数之间相互关系。结果HIMP增益与SHIMP增益呈线性正相关，并且HIMP增益大于SHIMP增益，差异具有统计学意义（t=5.890，r=0.956，P均=0.000）。HIMP潜伏期大于SHIMP潜伏期，差异具有统计学意义（t=-3.360，P=0.001），但无相关性（r=0.180，P=0.196）。HIMP扫视振幅与SHIMP扫视振幅呈负相关（r=-0.484，P=0.000），HIMP扫视百分比与SHIMP显性扫视百分比呈负相关（r=-0.604，P=0.000）。HIMP增益与HIMP扫视潜伏期、振幅及百分比均呈负相关，且均具有统计学意义（P＜0.05）。SHIMP增益与SHIMP代偿性扫视振幅及百分比呈正相关，具有统计学意义（P＜0.05）。SHIMP增益与SHIMP扫视潜伏期无相关性（r=-0.044，P=0.756）。结论SHIMP和HIMP均可检查水平性角前庭眼动反射（VOR）的直接通路，代偿性扫视和反代偿性扫视的增益、振幅和扫视产生的百分比可作为动态观察指标评估前庭功能。两者参数变化对评估VOR通路的损伤和恢复情况起到一定指导意义。

Correlation analysis of parameters between head impulse paradigm and suppression head impulse paradigm

ObjectiveTo verify the complementary effect of head impulse paradigm (HIMP) and suppression head impulse paradigm (SHIMP) in vestibulo ocular reflex.MethodsThirty three patients with superior vestibular neuritis and 10 normal subjects (20 ears) were selected. Matching analyses on parameters including the gain of HIMP and SHIMP, latency and amplitude of saccades, and the percentage of saccades were made between the affected side of patients and the normal group to compare their relationships.ResultsThere was a linear positive correlation between the HIMP gain and the SHIMP gain, the former was greater than the latter,, and the difference was statistically significant (t=5.890, r=0.956, all P=0.000). The latency of HIMP was higher than that of SHIMP (t=-3.360,P=0.001), but there was no correlation r=0.180,(P=0.196). The saccades amplitude of HIMP was negatively correlated with that of SHIMP (r=-0.484, P=0.000), and the saccades percentage of HIMP was negatively correlated with that of SHIMP (r=-0.604, P=0.000). The gain of HIMP was negatively correlated with the saccades latency, amplitude and percentage of HIMP. The gain of SHIMP was positively correlated with the compensatory saccade amplitude and percentage of SHIMP(P<0.05). There was no correlation between the gain of SHIMP and the saccades latency of SHIMP(r=-0.044, P=0.756).ConclusionBoth SHIMP and HIMP can be used to test the direct pathway of horizontal angular vestibulo ocular reflex (aVOR). The gain, amplitude, and the percentage of saccades are dynamic indexes to evaluate vestibular function. Their parameter changes may have certain guiding significance to the evaluation of the damage and recovery of VOR pathway.