Supraglottic subepithelial benign mass lesions: Focus on clinical features of sialolipoma-like lesion |
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| Authors: | Tomoyasu Tachibana Shin Kariya Yoji Wani Yasutoshi Komatsubara Yuto Naoi Kazunori Kuroda Soichiro Fushimi Machiko Hotta Katsuya Haruna Tami Nagatani Takuma Makino Yuko Kataoka Kazunori Nishizaki |
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| Institution: | 1. Departments of Otolaryngology, Japanese Red Cross Society Himeji Hospital, 12-1 Shimoteno 1-Chome, Himeji City, Hyogo 670-8540, Japan;2. Department of Otolaryngology Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama City, Okayama 700-8558, Japan;3. Departments of Pathology, Japanese Red Cross Society Himeji Hospital, 12-1 Shimoteno 1-Chome, Himeji City, Hyogo 670-8540, Japan;4. Departments of Inspection technology, Japanese Red Cross Society Himeji Hospital, 12-1 Shimoteno 1-Chome, Himeji City, Hyogo 670-8540, Japan;1. Department of Anatomy and Neurobiology, National Defense Medical College, Tokorozawa, 359-8513, Japan;2. Department of Otolaryngology, Head and Neck Surgery, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan;3. Division of Bioinformation and Therapeutic Systems, National Defense Medical College Research Institute, Tokorozawa, 359-8513, Japan;1. Department of Gastroenterology and Hepatology, Tokyo Medical University, Tokyo, Japan;2. Department of Otorhinolaryngology, Head and Neck Surgery, Tokyo Medical University, Tokyo, Japan;3. Endoscopy Center, Tokyo Medical University Hospital, Tokyo, Japan;1. Divisions of Gastroenterology, Ise Red Cross Hospital, 471-2, 1, Funae, Ise, Mie 516-8512, Japan;2. Divisions of Otolaryngology-Head and Neck Surgery, Ise Red Cross Hospital, Mie, Japan;3. Divisions of Radiation Oncology, Ise Red Cross Hospital, Mie, Japan;1. Department of Medical Technology, Ise Red Cross Hospital, 1-471-2 Funae, Ise, Mie 516-8512, Japan;2. Division of Health Sciences, Graduate School of Medical Sciences, Kanazawa University, 5-11-80, Kodatsuno, Kanazawa, Ishikawa 920-0942, Japan;3. Department of Radiation Oncology, Ise Red Cross Hospital, 1-471-2 Funae, Ise, Mie 516-8512, Japan;4. Department of Biostatistics, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8131, Japan;5. Proton Therapy Center, Fukui Prefectural Hospital, 2-8-1 Yotsui, Fukui, Fukui 910-8526, Japan;6. Department of Oral Maxillofacial Surgery, The Nippon Dental University Niigata Hospital, 1-8 Hamaura-cho, Niigata, Niigata 951-8151, Japan;7. Department of Oral Health, Faculty of Health and Medical Sciences, Meikai University, 1 Meikai, Urayasu, Chiba 279-8550, Japan;1. Speech Science, School of Psychology, The University of Auckland, New Zealand;2. Starship Children''s Hospital, Auckland, New Zealand;3. Section of Audiology, The University of Auckland, New Zealand;4. Eisdell Moore Centre for Research in Hearing and Balance, New Zealand |
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| Abstract: | ObjectivesSialolipoma has been classified as a benign soft tissue lesion in the 2017 World Health Organization classification of head and neck tumors. To our knowledge, only one case of laryngeal sialolipoma has been reported in the English literature. We conducted a retrospective study to identify clinical characteristics of supraglottic sialolipoma-like lesion and differentiate it from other supraglottic subepithelial masses.MethodsMedical records of 16 patients with supraglottic subepithelial benign mass lesions who underwent histological evaluation between 2003 and 2019 were retrospectively analyzed. Sialolipoma-like lesion was defined as a local finding of a well-circumscribed gross mass with pathological presence of salivary gland-like parenchymal lobules with evenly interspersed adipose tissue.ResultsEight patients showed histological positivity for sialolipoma-like lesion, 3 for amyloidosis, 2 for hemangioma, and 1 each for cyst, lymphoid hyperplasia, and chondrometaplasia. Sialolipoma-like lesion tended to be predominant among men; those affected had a mean age of 52.8 (range, 39–74) years. By contrast, among patients with amyloidosis, the ratio of men to women was 1:2 (100% vs. 33%; p = 0.055). Fiberscopic examination of all patients with sialolipoma-like lesions identified well-circumscribed, yellowish masses, closely resembling local amyloidosis findings. Sialolipoma-like lesion was associated with a significantly higher body-mass index (BMI; 27.4 ± 2.8 kg/m2) than amyloidosis (21.6 ± 1.4 kg/m2; p = 0.014). The transoral approach was used for lesion resection in all patients with sialolipoma-like lesion. No patient experienced postoperative recurrence.ConclusionLaryngeal sialolipoma-like lesion might be more prevalent than was previously reported, and histological examination is important to differentiate it from amyloidosis. Supraglottic sialolipoma-like lesion must be differentially diagnosed in patients with high BMI presenting with well-circumscribed, yellowish supraglottic masses. |
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