喉癌患者手术前后凝血状态的动态观察

目的 :探讨喉癌患者手术前后的凝血状态。方法 :测定 46例喉癌患者行全喉切除术前 1天及术后第1、10天的凝血系统 8项参数 ,观察其测值的变化 ;并以 82例健康人为对照组 ,进行比较。结果 :患者术前即存在抗凝活性明显降低 ,并伴有纤溶活性增强 ,手术创伤使上述异常进一步加重。随着癌肿的切除和手术创伤的恢复 ,患者抗凝及纤溶系统逐渐恢复至正常水平。结论 :喉癌患者存在一定程度的凝血障碍 ,而手术能进一步加重其障碍程度 ,故临床上应高度重视对患者的抗凝及纤溶系统的监测 ,以防血栓及出血性疾病的发生。

Study on the coagulation state of laryngeal cancer patients before and after operation

Objective:To explore the coagulation state of laryngeal cancer patients before and after operation.Method:The eight parameters of coagulant system of 46 laryngeal cancer patients were examined before operation, l day and 10 days after operation, and compared with control group.Result:The result suggests, anticoagulant activity decreased and fibrinolytic activity increased in laryngeal cancer patients before operation. Laryngeotomy trauma may worsen the abnormality. With the incision of tumors and recovery from operation trauma, anticoagulant activity and fibrinolytic activity of the patients gradually returned to normal level.Conclusion:Coagulation disorders in laryngeal cancer patients had existed in a way. With operation trauma, it may worsen the abnormality. So anticoagulant and fibrinolytic systems of these patients should be taken seriously to prevent thrombosis and bleeding.