| 白细胞介素-18在变应性鼻炎中的作用 |
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| 引用本文： | 张明,刘立思.白细胞介素-18在变应性鼻炎中的作用[J].临床耳鼻咽喉头颈外科杂志,2004,18(5):257-258. |
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| 作者姓名： | 张明 刘立思 |
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| 作者单位： | 华中科技大学同济医学院附属同济医院耳鼻咽喉科,武汉,430030 |
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| 摘 要： | 目的 :探讨白细胞介素 18(IL 18)在变应性鼻炎发生发展中的作用。方法 :采用双抗体夹心ELISA法检测 30例变应性鼻炎患者 (鼻炎组 )和 2 0例健康志愿者 (对照组 )血清中IL 18的含量。结果 :鼻炎组血清IL 18含量 (4 2 4 .12± 6 0 .4 7)ng/L]高于对照组 (2 10 .71± 5 7.37)ng/L],其差异有统计学意义 (P <0 .0 1) ;变应性鼻炎伴哮喘者 (5 91.19± 4 6 .5 4 )ng/L]高于不伴哮喘者 (35 2 .5 2± 6 4 .2 5 )ng/L],其差异亦有统计学意义 (P <0 .0 5 )。结论 :变应性鼻炎患者血清IL 18表达增高 ,在变应性炎症的持续存在和恶化过程中起重要作用。
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| 关 键 词： | 白细胞介素-18 鼻炎 变应性 |
| 文章编号： | 1001-1781(2004)05-0257-02 |
| 修稿时间： | 2003年7月30日 |
The role of IL-18 in allergic rhinitis |
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| ZHANG Ming,LIU Lisi.The role of IL-18 in allergic rhinitis[J].Journal of Clinical Otorhinolaryngology,2004,18(5):257-258. |
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| Authors: | ZHANG Ming LIU Lisi |
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| Institution: | Department of Otorhinolaryngology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. |
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| Abstract: | OBJECTIVE: To investigate the roles of IL-18 in the perennial allergic rhinitis (PAR). METHOD: We measured IL-18 concentration in sera of 30 PAR patients and 20 health control subjects with enzyme-linked immunosorbent assay (ELISA). RESULT: The concentration of IL-18 in PAR patients (424.12 +/- 60. 47) ng/L] was significantly higher compared to health control subjects (210.71 +/- 57. 37) ng/L](P<0.01) and the concentration of L-18 in PAR patients with asthma (591.19 +/- 46.54) ng/L] was significantly higher than those without asthma (352.52 +/- 64.25) ng/L](P<0.05). CONCLUSION: The IL-18 is high in PAR patients and the persistence of elevated IL-18 concentration suggests its role in the expression of persistence and exacerbation of allergic inflammation. |
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| Keywords: | Interleukin 18 Rhinitis allergic |
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