金双歧片治疗极低出生体质量儿喂养不耐受

目的探讨金双歧片改善极低出生体质量儿(VLBWI)喂养不耐受情况。方法将60例VLBWI随机分成金双歧治疗组及对照组,每组各30例。两组均予静脉营养及早产儿配方奶喂哺,治疗组在早产儿配方奶喂哺时添加金双歧片,每次0.5片,3次/d。记录每次喂奶量、第1次开始喂奶时间和达全胃肠喂养时间、喂奶前胃潴留量,生后d21时体质量。结果治疗组较对照组无胃潴留的比例明显增加(t=6.84P<0.01)。达到全胃肠道喂养所需时间治疗组平均为11d,对照组平均为15d,治疗组较对照组明显缩短(t=11.39P<0.01)。治疗组生后d21体质量较对照组明显增加(t=2.291P<0.05)。微生态制剂治疗过程中无不良反应发生。结论金双歧可改善VLBWI喂养不耐受,促进患儿体质量增长,缩短达到全胃肠喂养时间。

Effect of Probiotics on Feeding Intolerance in Infants with Very Low Birth Weight

Objective To explore effect of probiotics on improving the feeding intolerance in very low birth weight infants(VLBWI). Methods Sixty cases of VLBWI were randomly divided into two groups, 30 infants as therapy group,another 30 infants as control group.All infants in two groups were given aggressive intravenous nutrition and enteral feeding with preterm formulars. At the same time, probiotics were administered combined with preterm formulars to infants in therapy group. Milk amount, gastric residual, initial time of enteral feeding, time required for full enteral feeding and body weight on day 21 after birth were all recorded.Results Rate of no gastric residual increased significantly in therapy group compared with that of control group(t=6.24 P<0.01). Time required for full enteral feeding was 11 days in therapy group, and 15 days in control group,the time was significantly shortened in therapy group(t=11.39 P<0.01).Body weight on day 21 after birth of infants in therapy group significantly increased compared with that of control group.Conclusion Probiotics can improve the feeding intolerance of VLBWI ,and increase the body weight and shorten the time required for full enteral feeding.